ArticlePloS one2011
The K153R polymorphism in the myostatin gene and muscle power phenotypes in young, non-athletic men.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Socceromics: A Systematic Review of Omics Technologies to Optimize Performance and Health in Soccer.International journal of molecular sciences · 2026Pooled it
- Pooled it
- Myostatin Research: From Molecular Understanding to Clinical Translation for Musculoskeletal and Metabolic Disorders.International journal of molecular sciences · 2026Review
- Humans with function-disrupting variants in the myostatin gene (MSTN) have increased skeletal muscle mass and strength, and less adiposity.Nature communications · 2026Article
- The influences of genetic polymorphisms in three candidate genes on the athletic performance of Korean athletes.Genes & genomics · 2025Article
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- Influence of genetic polymorphism on sports talent performance versus non-athletes: a systematic review and meta-analysis.BMC sports science, medicine & rehabilitation · 2024Article
- Real-world trough concentrations and effectiveness of long-acting cabotegravir and rilpivirine: a multicenter prospective observational study in Switzerland.The Lancet regional health. Europe · 2024Article
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- Polygenic Models Partially Predict Muscle Size and Strength but Not Low Muscle Mass in Older Women.Genes · 2022Article
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- Effects of Training Status and Exercise Mode on Global Gene Expression in Skeletal Muscle.International journal of molecular sciences · 2021Article
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- Association of whole mtDNA, an NADPH G11914A variant, and haplogroups with high physical performance in an elite military troop.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021Article
- The Association of Multiple Gene Variants with Ageing Skeletal Muscle Phenotypes in Elderly Women.Genes · 2020Article
- Genetic test for the personalization of sport training.Acta bio-medica : Atenei Parmensis · 2020Review
- Cellular Aspects of Muscle Specialization Demonstrate Genotype - Phenotype Interaction Effects in Athletes.Frontiers in physiology · 2019Article
- Beyond the Big Five: Investigating Myostatin Structure, Polymorphism and Expression inFrontiers in genetics · 2019Article
- Relationship of muscle function to circulating myostatin, follistatin and GDF11 in older women and men.BMC geriatrics · 2018Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Lys(K)153Arg(R) polymorphism in exon 2 (rs1805086, 2379 A>G replacement) of the myostatin (MSTN) gene is a candidate to influence skeletal muscle phenotypes. We examined the association between the MSTN K153R polymorphism and 'explosive' leg power, assessed during sprint (30 m) and stationary jumping tests [squat (SJ) and counter-movement jumps (CMJ)] in non-athletic young adults (University students) [n = 281 (214 men); age: 21-32 years]. We also genotyped the MSTN exonic variants E164K (rs35781413), I225T, and P198A, yet no subject carried any of these variant MSTN alleles. As for the K153R polymorphism, we found only one woman with the KR genotype; thus, we presented the results only for men. The results of a one-way ANCOVA (with age, weight and height entered as covariates) showed that men with the KR genotype (n = 15) had a worse performance in vertical jumps compared with those with the KK genotype [SJ: vertical displacement of center of gravity (CG) of 35.17 ± 1.42 vs. 39.06 ± 0.39 cm, respectively, P = 0.009; CMJ: vertical displacement of CG of 36.44 ± 1.50 vs. 40.63 ± 0.41 cm, respectively, P = 0.008]. The results persisted after adjusting for multiple comparisons according to Bonferroni. Performance in 30 m sprint tests did however not differ by K153R genotypes. In summary, the MSTN K153R polymorphism is associated with the ability to produce 'peak' power during muscle contractions, as assessed with vertical jump tests, in young non-athletic men. Although more research is still needed, this genetic variation is among the numerous candidates to explain, alone or in combination with other polymorphisms, individual variations in muscle phenotypes.
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