ArticlePloS one2011
Standing genetic variation in contingency loci drives the rapid adaptation of Campylobacter jejuni to a novel host.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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Who cites it
74 citing papers in PubMed, 98 citations in OpenAlex.
- Variation in multiple classes of simple sequence repeats can alter drug susceptibility inbioRxiv : the preprint server for biology · 2026Article
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- Collateral effects of antibiotic resistance in Campylobacter jejuni.FEMS microbiology letters · 2026Article
- Random amplified polymorphic DNA polymerase chain reaction was used to analyze the genotype and diversity ofOpen veterinary journal · 2025Article
- Pathogen contingency loci and the evolution of host specificity: Simple sequence repeats mediate Bartonella adaptation to a wild rodent host.PLoS pathogens · 2024Article
- Diversity analysis of livestock-associatedOpen veterinary journal · 2024Article
- Mutation bias and adaptation in bacteria.Microbiology (Reading, England) · 2023Review
- First study on molecular epidemiology of caseous lymphadenitis in slaughtered sheep and goats in Duhok Province, Iraq.Open veterinary journal · 2023Article
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- Genomic insights into zoonotic transmission and antimicrobial resistance in Campylobacter jejuni from farm to fork: a one health perspective.Gut pathogens · 2022Review
- Genomic Analysis Reveals That Isolation Temperature on Selective Media Introduces Genetic Variation inPathogens (Basel, Switzerland) · 2022Article
- Simple sequence repeat insertion induced stability and potential 'gain of function' in the proteins of extremophilic bacteria.Extremophiles : life under extreme conditions · 2022Article
- Serial passage in an insect host indicates genetic stability of the human probioticEvolution, medicine, and public health · 2022Article
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- Survival of Salmonella Under Heat Stress is Associated with the Presence/Absence of CRISPR Cas Genes and Iron Levels.Current microbiology · 2021Article
- Phase Variation During Host Colonization and Invasion byFrontiers in microbiology · 2021Review
- Molecular diagnostics ofAIMS microbiology · 2021Article
- Identification and differentiation ofVeterinary world · 2020Article
- Microevolution of Campylobacter jejuni during long-term infection in an immunocompromised host.Scientific reports · 2020Article
- Guide-free Cas9 from pathogenicScience advances · 2020Article
14 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The genome of the food-borne pathogen Campylobacter jejuni contains multiple highly mutable sites, or contingency loci. It has been suggested that standing variation at these loci is a mechanism for rapid adaptation to a novel environment, but this phenomenon has not been shown experimentally. In previous work we showed that the virulence of C. jejuni NCTC11168 increased after serial passage through a C57BL/6 IL-10(-/-) mouse model of campylobacteriosis. Here we sought to determine the genetic basis of this adaptation during passage. Re-sequencing of the 1.64 Mb genome to 200-500 X coverage allowed us to define variation in 23 contingency loci to an unprecedented depth both before and after in vivo adaptation. Mutations in the mouse-adapted C. jejuni were largely restricted to the homopolymeric tracts of thirteen contingency loci. These changes cause significant alterations in open reading frames of genes in surface structure biosynthesis loci and in genes with only putative functions. Several loci with open reading frame changes also had altered transcript abundance. The increase in specific phases of contingency loci during in vivo passage of C. jejuni, coupled with the observed virulence increase and the lack of other types of genetic changes, is the first experimental evidence that these variable regions play a significant role in C. jejuni adaptation and virulence in a novel host.
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