ArticlePloS one2011
The effect of a DNA repair gene on cellular invasiveness: XRCC3 over-expression in breast cancer cells.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- E2F1 Promotes Progression of Bladder Cancer by Modulating RAD54L Involved in Homologous Recombination Repair.International journal of molecular sciences · 2020Article
- Genotypic distribution of single nucleotide polymorphisms in oral cancer: global scene.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
- Article
- DNA-PKcs plays role in cancer metastasis through regulation of secreted proteins involved in migration and invasion.Cell cycle (Georgetown, Tex.) · 2015Article
- DNA damage response genes and the development of cancer metastasis.Radiation research · 2014Review
- Rad51 expression is a useful predictive factor for the efficacy of neoadjuvant chemoradiotherapy in squamous cell carcinoma of the esophagus.Annals of surgical oncology · 2014Article
- An appraisal of RECQ1 expression in cancer progression.Frontiers in genetics · 2014Article
- Identification of RECQ1-regulated transcriptome uncovers a role of RECQ1 in regulation of cancer cell migration and invasion.Cell cycle (Georgetown, Tex.) · 2014Article
- Discoidin domain receptor functions in physiological and pathological conditions.International review of cell and molecular biology · 2014Review
- Human CST abundance determines recovery from diverse forms of DNA damage and replication stress.Cell cycle (Georgetown, Tex.) · 2014Article
- Article
- Discoidin domain receptor tyrosine kinases: new players in cancer progression.Cancer metastasis reviews · 2012Review
- DNA damage and breast cancer.World journal of clinical oncology · 2011Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over-expression of DNA repair genes has been associated with resistance to radiation and DNA-damage induced by chemotherapeutic agents such as cisplatin. More recently, based on the analysis of genome expression profiling, it was proposed that over-expression of DNA repair genes enhances the invasive behaviour of tumour cells. In this study we present experimental evidence utilizing functional assays to test this hypothesis. We assessed the effect of the DNA repair proteins known as X-ray complementing protein 3 (XRCC3) and RAD51, to the invasive behavior of the MCF-7 luminal epithelial-like and BT20 basal-like triple negative human breast cancer cell lines. We report that stable or transient over-expression of XRCC3 but not RAD51 increased invasiveness in both cell lines in vitro. Moreover, XRCC3 over-expressing MCF-7 cells also showed a higher tumorigenesis in vivo and this phenotype was associated with increased activity of the metalloproteinase MMP-9 and the expression of known modulators of cell-cell adhesion and metastasis such as CD44, ID-1, DDR1 and TFF1. Our results suggest that in addition to its' role in facilitating repair of DNA damage, XRCC3 affects invasiveness of breast cancer cell lines and the expression of genes associated with cell adhesion and invasion.
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