ArticlePloS one2011
Evolutionary analyses of Staphylococcus aureus identify genetic relationships between nasal carriage and clinical isolates.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 62 citations in OpenAlex.
- Molecular investigation of biofilm-forming genes in staphylococci isolated from dogs in Ilam, Iran.Veterinary research forum : an international quarterly journal · 2026Article
- Nasal microbiome inhabitants with anti-Microbiology spectrum · 2025Article
- Characterization of methicillin-resistant Staphylococcus aureus strains colonizing the nostrils of Spanish children.MicrobiologyOpen · 2021Article
- Control of Methicillin-ResistantFrontiers in microbiology · 2020Article
- Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology.Clinical microbiology reviews · 2018Review
- Naturally occurring polymorphisms in the virulence regulator Rsp modulate Staphylococcus aureus survival in blood and antibiotic susceptibility.Microbiology (Reading, England) · 2018Article
- Host innate inflammatory factors and staphylococcal protein A influence the duration of human Staphylococcus aureus nasal carriage.Mucosal immunology · 2016Article
- The single-species metagenome: subtypingPeerJ · 2016Article
- Selected Factors of Innate Immunity in Healthy Individuals with S. aureus Nasal Carriage.Frontiers in microbiology · 2016Article
- Endovascular infections caused by methicillin-resistant Staphylococcus aureus are linked to clonal complex-specific alterations in binding and invasion domains of fibronectin-binding protein A as well as the occurrence of fnbB.Infection and immunity · 2015Article
- Staphylococcus aureus nasal carriage among healthcare workers in Kisangani, the Democratic Republic of the Congo.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Article
- Observational
- A recommendation to perform a blood culture before the administration of intravenous antibiotics increased the detection of Staphylococcus aureus bacteremia.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Article
- The genetic structure of Staphylococcus aureus populations from the Southwest Pacific.PloS one · 2014Article
- Longitudinal genetic analyses of Staphylococcus aureus nasal carriage dynamics in a diverse population.BMC infectious diseases · 2013Article
- Emerging functions for the Staphylococcus aureus RNome.PLoS pathogens · 2013Review
- Protective activity of the CnaBE3 domain conserved among Staphylococcus aureus Sdr proteins.PloS one · 2013Article
- Comparison of Staphylococcus aureus isolates associated with food intoxication with isolates from human nasal carriers and human infections.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Article
- Antistaphylococcal activity of bacteriophage derived chimeric protein P128.BMC microbiology · 2012Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Nasal carriage of Staphylococcus aureus has long been hypothesized to be a major vector for the transmission of virulent strains throughout the community. To address this hypothesis, we have analyzed the relatedness between a cohort of nasal carriage strains and clinical isolates to understand better the genetic conformity therein. To assess the relatedness between nasal carriage and clinical isolates of S. aureus, a genetic association study was conducted using multilocus sequence typing (MLST) and typing of the hypervariable regions of clumping factor and fibronectin binding protein genes. At all loci analyzed, genetic associations between both nasal carriage and clinical isolates were observed. Computational analyses of MLST data indicate that nasal carriage and clinical isolates belong to the same genetic clusters (clades), despite differences in sequence type assignments. Genetic analyses of the hypervariable regions from the clumping factor and fibronectin binding protein genes revealed that not only do clinically relevant strains belong to identical genetic lineages as the nasal carriage isolates within our cohort, but they also exhibit 100% sequence similarity within these regions. The findings of this report indicate that strains of S. aureus being carried asymptomatically throughout the community via nasal colonization are genetically related to those responsible for high levels of morbidity and mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.