Evidence map›Paper›PMID 21283601›Full record

ArticleF1000 biology reports2010

Creating transplant tolerance by taming adverse intragraft innate immunity.

Dusan Hanidziar, Maria Koulmanda, Terry B Strom

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in F1000 biology reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Dusan HanidziarDepartments of Medicine and Surgery, Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, E/CLS 608 Boston, MA 02215 USA.
Maria Koulmanda
Terry B Strom

Funding

Transgenic / Knock-out mouse coreP01AI073748 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI BEHAR, SAMUEL M · 2008 to 2019
$17.1M
T Cell Fate as a Determinant of Alloimmune ResponsesP01AI041521 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI STROM, TERRY B. · 1997 to 2011
$15.9M
Inflammation and T Cell Memory: Inter-related Barriers to Allograft ToleranceU19DK080652 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI STROM, TERRY B. · 2007 to 2011
$7.5M
THORACIC ALLOGRAFT TOLERANCE IN NON-HUMAN PRIMATESU19AI066705 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 2005 to 2009
$6.3M
Taming inflammation to create transplant toleranceU01AI102427 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KOULMANDA, MARIA, STROM, TERRY B. · 2012 to 2016
$4.0M
Role of interleukin 21 in the allograft responseF32AI084373 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI HANIDZIAR, DUSAN · 2009 to 2009
$52k
NIAID NIH HHS F32 AI084373NIAID NIH HHS P01 AI041521NIAID NIH HHS P01 AI073748NIAID NIH HHS U01 AI102427NIAID NIH HHS U19 AI066705NIDDK NIH HHS U19 DK080652
6 · The paper itself

Abstract

Certain forms of inflammation of an allograft are highly detrimental to the induction and maintenance of transplant tolerance as they foster stable commitment to graft-destructive, not graft-protective, forms of T-cell immunity. Hence, a reduction in adverse tissue inflammation may prove crucial in facilitating the induction and maintenance of a long-lasting state of transplant tolerance.

Identifiers

PMID21283601
PMCPMC3026643

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.