ArticleMolecular systems biology2011
Substrate-dependent control of MAPK phosphorylation in vivo.
Article in Molecular systems biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 84 citations in OpenAlex.
- Dynamics and Sensitivity of Signaling Pathways.Current pathobiology reports · 2022Article
- Article
- A Practical Step-by-Step Guide for Quantifying Retroactivity in Gene Networks.Methods in molecular biology (Clifton, N.J.) · 2021Article
- It's about time: Analysing simplifying assumptions for modelling multi-step pathways in systems biology.PLoS computational biology · 2020Article
- Activation-induced substrate engagement in ERK signaling.Molecular biology of the cell · 2020Article
- When More Is Less: Dual Phosphorylation Protects Signaling Off State against Overexpression.Biophysical journal · 2018Article
- A quantitative model of developmental RTK signaling.Developmental biology · 2018Review
- Outstanding questions in developmental ERK signaling.Development (Cambridge, England) · 2018Review
- Exploring the intrinsic behaviour of multisite phosphorylation systems as part of signalling pathways.Journal of the Royal Society, Interface · 2018Article
- A double-edged sword: The world according to Capicua in cancer.Cancer science · 2017Review
- Signaling Architectures that Transmit Unidirectional Information Despite Retroactivity.Biophysical journal · 2017Article
- Two faces of competition: target-mediated reverse signalling in microRNA and mitogen-activated protein kinase regulatory networks.IET systems biology · 2017Review
- Minibrain and Wings apart control organ growth and tissue patterning through down-regulation of Capicua.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Signaling cascades transmit information downstream and upstream but unlikely simultaneously.BMC systems biology · 2016Article
- Long-term dynamics of multisite phosphorylation.Molecular biology of the cell · 2016Article
- Control theory meets synthetic biology.Journal of the Royal Society, Interface · 2016Review
- Mapping the binding interface of ERK and transcriptional repressor Capicua using photocrosslinking.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- A technique for determining the signs of sensitivities of steady states in chemical reaction networks.IET systems biology · 2014Article
- A load driver device for engineering modularity in biological networks.Nature biotechnology · 2014Article
- Paradoxical results in perturbation-based signaling network reconstruction.Biophysical journal · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
Abstract
Phosphorylation of the mitogen-activated protein kinase (MAPK) is essential for its enzymatic activity and ability to control multiple substrates inside a cell. According to the current models, control of MAPK phosphorylation is independent of its substrates, which are viewed as mere sensors of MAPK activity. Contrary to this modular view of MAPK signaling, our studies in the Drosophila embryo demonstrate that substrates can regulate the level of MAPK phosphorylation in vivo. We demonstrate that a twofold change in the gene dosage of a single substrate can induce a significant change in the phosphorylation level of MAPK and in the conversion of other substrates. Our results support a model where substrates of MAPK counteract its dephosphorylation by phosphatases. Substrate-dependent control of MAPK phosphorylation is a manifestation of a more general retroactive effect that should be intrinsic to all networks with covalent modification cycles.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.