ArticleMolecular systems biology2011
Programming an in vitro DNA oscillator using a molecular networking strategy.
Article in Molecular systems biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 92 papers.
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Who cites it
92 citing papers in PubMed.
- Synthetic dynamic transcription frameworks and their applications.Nature chemistry · 2026Review
- Article
- Developmental assembly of multi-component polymer systems through interconnected synthetic gene networks in vitro.Nature communications · 2024Article
- Temporally controlled multistep division of DNA droplets for dynamic artificial cells.Nature communications · 2024Article
- Coupling Exponential to Linear Amplification for Endpoint Quantitative Analysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- DNA-empowered synthetic cells as minimalistic life forms.Nature reviews. Chemistry · 2024Review
- Molecular robotic agents that survey molecular landscapes for information retrieval.Nature communications · 2024Article
- Selenium catalysis enables negative feedback organic oscillators.Nature communications · 2024Article
- DNA as a universal chemical substrate for computing and data storage.Nature reviews. Chemistry · 2024Review
- DNA Reaction System That Acquires Classical Conditioning.ACS synthetic biology · 2024Article
- DNA droplets for intelligent and dynamical artificial cells: from the viewpoint of computation and non-equilibrium systems.Interface focus · 2023Review
- Alternate Strategies to Induce Dynamically Modulated Transient Transcription Machineries.ACS nano · 2023Article
- Multiple TMA-aided CRISPR/Cas13a platform for highly sensitive detection of IL-15 to predict immunotherapeutic response in nasopharyngeal carcinoma.Journal for immunotherapy of cancer · 2023Article
- PhotocleavableChemical reviews · 2023Review
- Dynamic Catalysis Guided by Nucleic Acid Networks and DNA Nanostructures.Bioconjugate chemistry · 2023Review
- Dynamic Transcription Machineries Guide the Synthesis of Temporally Operating DNAzymes, Gated and Cascaded DNAzyme Catalysis.ACS nano · 2023Article
- Orthogonal Enzyme-Driven Timers for DNA Strand Displacement Reactions.Journal of the American Chemical Society · 2022Article
- Standardized excitable elements for scalable engineering of far-from-equilibrium chemical networks.Nature chemistry · 2022Article
- Positive feedback drives a secondary nonlinear product burst during a biphasic DNA amplification reaction.The Analyst · 2022Article
- Cascaded dissipative DNAzyme-driven layered networks guide transient replication of coded-strands as gene models.Nature communications · 2022Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Living organisms perform and control complex behaviours by using webs of chemical reactions organized in precise networks. This powerful system concept, which is at the very core of biology, has recently become a new foundation for bioengineering. Remarkably, however, it is still extremely difficult to rationally create such network architectures in artificial, non-living and well-controlled settings. We introduce here a method for such a purpose, on the basis of standard DNA biochemistry. This approach is demonstrated by assembling de novo an efficient chemical oscillator: we encode the wiring of the corresponding network in the sequence of small DNA templates and obtain the predicted dynamics. Our results show that the rational cascading of standard elements opens the possibility to implement complex behaviours in vitro. Because of the simple and well-controlled environment, the corresponding chemical network is easily amenable to quantitative mathematical analysis. These synthetic systems may thus accelerate our understanding of the underlying principles of biological dynamic modules.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.