ArticleGenome biology and evolution2011
Comparative genomic analysis of the Streptococcus dysgalactiae species group: gene content, molecular adaptation, and promoter evolution.
Article in Genome biology and evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 54 citations in OpenAlex.
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- Phylogenetic analysis and accessory genome diversity reveal insight into the evolutionary history ofFrontiers in microbiology · 2022Article
- Streptococcal Infections in Marine Mammals.Microorganisms · 2021Review
- New Insights onFrontiers in microbiology · 2021Article
- Development and Application of a Prophage Integrase Typing Scheme for Group BFrontiers in microbiology · 2020Article
- Incidence, clinical characteristics, and outcomes of Streptococcus dysgalactiae subspecies equisimilis bacteremia in a tertiary hospital: comparison with S. agalactiae bacteremia.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Article
- Pathogenicity Induced by Invasive Infection ofFrontiers in microbiology · 2018Article
- Whole-Genome Sequence Analysis of Antimicrobial Resistance Genes inFrontiers in veterinary science · 2017Article
- Molecular Characterization of Invasive Streptococcus dysgalactiae subsp. equisimilis, Japan.Emerging infectious diseases · 2016Article
- Comparative Genomic Analysis of the ICESa2603 Family ICEs and Spread of erm(B)- and tet(O)-Carrying Transferable 89K-Subtype ICEs in Swine and Bovine Isolates in China.Frontiers in microbiology · 2016Article
- Molecular epidemiology and genomics of group A Streptococcus.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2015Review
- Comparative genomic and phenomic analysis of Clostridium difficile and Clostridium sordellii, two related pathogens with differing host tissue preference.BMC genomics · 2015Article
- New tricks from an old cow: infective endocarditis caused by Streptococcus dysgalactiae subsp. dysgalactiae.Journal of clinical microbiology · 2015Article
- Conjugative transfer of ICESde3396 between three β-hemolytic streptococcal species.BMC research notes · 2014Article
- Sequence diversity of sicG among group C and G Streptococcus dysgalactiae subspecies equisimilis isolates associated with human infections in western Norway.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Article
- Horizontal gene transfer and recombination in Streptococcus dysgalactiae subsp. equisimilis.Frontiers in microbiology · 2014Article
- PSP: rapid identification of orthologous coding genes under positive selection across multiple closely related prokaryotic genomes.BMC genomics · 2013Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Comparative genomics of closely related bacterial species with different pathogenesis and host preference can provide a means of identifying the specifics of adaptive differences. Streptococcus dysgalactiae (SD) is comprised of two subspecies: S. dysgalactiae subsp. equisimilis is both a human commensal organism and a human pathogen, and S. dysgalactiae subsp. dysgalactiae is strictly an animal pathogen. Here, we present complete genome sequences for both taxa, with analyses involving other species of Streptococcus but focusing on adaptation in the SD species group. We found little evidence for enrichment in biochemical categories of genes carried by each SD strain, however, differences in the virulence gene repertoire were apparent. Some of the differences could be ascribed to prophage and integrative conjugative elements. We identified approximately 9% of the nonrecombinant core genome to be under positive selection, some of which involved known virulence factors in other bacteria. Analyses of proteomes by pooling data across genes, by biochemical category, clade, or branch, provided evidence for increased rates of evolution in several gene categories, as well as external branches of the tree. Promoters were primarily evolving under purifying selection but with certain categories of genes evolving faster. Many of these fast-evolving categories were the same as those associated with rapid evolution in proteins. Overall, these results suggest that adaptation to changing environments and new hosts in the SD species group has involved the acquisition of key virulence genes along with selection of orthologous protein-coding loci and operon promoters.
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