Evidence map›Paper›PMID 21282546›Full record

Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2011

Automated symptom alerts reduce postoperative symptom severity after cancer surgery: a randomized controlled clinical trial.

Charles S Cleeland, Xin Shelley Wang, Qiuling Shi, Tito R Mendoza, Sherry L Wright, Madonna D Berry, Donna Malveaux, Pankil K Shah, Ibrahima Gning, Wayne L Hofstetter and 2 more

2 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 190 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
190citing papers in PubMed, 19 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03419156 naterminatednot on this mapstarted 2018, after this paper: background citation

Effect of a Short Message Service Intervention on Patients With Short Bowel Syndrome

TypeinterventionalSponsorSt. Louis UniversityRan2018 to 2019Enrolled5ConditionsShort Bowel SyndromeArmsText Message Arm Intervention
NCT07352410 nacompletednot on this mapstarted 2026, after this paper: background citation

Safety and Early Clinical Performance of High-Purity Type I Collagen Augmentation in Arthroscopic Meniscal Repair: A Prospective Feasibility Study

TypeinterventionalSponsorAdichunchanagiri Institute of Medical Sciences, B G NagaraRan2026 to 2026Enrolled18ConditionsMeniscus Tear, Knee Meniscus Injury, Meniscal Repair, Knee Arthroscopy (for Diagnostic or Therapy)ArmsHigh-Purity Type I Collagen
3 · Its place in the literature

Who cites it

190 citing papers in PubMed, 19 syntheses or guidelines pooled it, 346 citations in OpenAlex.

  1. Electronic patient-reported outcome platforms used in hematological cancers: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  5. Nurse-led telehealth interventions for symptom management in patients with cancer receiving systemic or radiation therapy: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
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  13. A systematic review of randomised controlled trials evaluating the use of patient-reported outcome measures (PROMs).Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019
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130 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Charles S CleelandThe University of Texas MD Anderson Cancer Center, Department of Symptom Research, 1515 Holcombe Blvd, Box 1450, Houston, TX 77030, USA. ccleeland@mdanderson.org
Xin Shelley Wang
Qiuling Shi
Tito R Mendoza
Sherry L Wright
Madonna D Berry
Donna Malveaux
Pankil K Shah
Ibrahima Gning
Wayne L Hofstetter
Joe B Putnam
Ara A Vaporciyan
The University of Texas MD Anderson Cancer Center · US

Funding

Reducing the Symptom Burden Produced by Aggressive Cancer TherapiesR01CA026582 · NCI · UNIVERSITY OF WISCONSIN MADISON · PI CLEELAND, CHARLES S · 1986 to 2013
$7.3M
NCI NIH HHS R01 CA026582
6 · The paper itself

Abstract

purposePatients receiving cancer-related thoracotomy are highly symptomatic in the first weeks after surgery. This study examined whether at-home symptom monitoring plus feedback to clinicians about severe symptoms contributes to more effective postoperative symptom control. PATIENTS AND

methodsWe enrolled 100 patients receiving thoracotomy for lung cancer or lung metastasis in a two-arm randomized controlled trial; 79 patients completed the study. After hospital discharge, patients rated symptoms twice weekly for 4 weeks via automated telephone calls. For intervention group patients, an e-mail alert was forwarded to the patient's clinical team for response if any of a subset of symptoms (pain, disturbed sleep, distress, shortness of breath, or constipation) reached a predetermined severity threshold. No alerts were generated for controls. Group differences in symptom threshold events were examined by generalized estimating equation modeling.

resultsThe intervention group experienced greater reduction in symptom threshold events than did controls (19% v 8%, respectively) and a more rapid decline in symptom threshold events. The difference in average reduction in symptom interference between groups was -0.36 (SE, 0.078; P = .02). Clinicians responded to 84% of e-mail alerts. Both groups reported equally high satisfaction with the automated system and with postoperative symptom control.

conclusionFrequent symptom monitoring with alerts to clinicians when symptoms became moderate or severe reduced symptom severity during the 4 weeks after thoracic surgery. Methods of automated symptom monitoring and triage may improve symptom control after major cancer surgery. These results should be confirmed in a larger study.

Indexed as

Decision Support Systems, ClinicalPatient DischargeReminder SystemsSelf ReportAgedDyspneaElectronic MailFemaleHumansLung NeoplasmsMaleMiddle AgedPostoperative CarePostoperative ComplicationsPostoperative PainSeverity of Illness Index

Identifiers

PMID21282546
PMCPMC3068055
OpenAlexW2150171887

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.