Evidence map›Paper›PMID 21282467›Full record

ReviewMolecular and cellular biology2011

Role of helix-loop-helix proteins during differentiation of erythroid cells.

Archana Anantharaman, I-Ju Lin, Joeva Barrow, Shermi Y Liang, Jude Masannat, John Strouboulis, Suming Huang, Jörg Bungert

Abstract readReview
In one paragraph

Review in Molecular and cellular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Orai1 acts as a novel CaExperimental & molecular medicine · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. TFII-I/Gtf2i and Erythro-Megakaryopoiesis.Frontiers in physiology · 2020
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Archana AnantharamanDepartment of Biochemistry and Molecular Biology, College of Medicine, Genetics Institute, Center for Epigenetics, Shands Cancer Center, University of Florida, Gainesville, FL 32610-0245, USA.
I-Ju Lin
Joeva Barrow
Shermi Y Liang
Jude Masannat
John Strouboulis
Suming Huang
Jörg Bungert

Funding

STRUCTURE/FUNCTION OF THE HUMAN B-GLOBIN LCRR01DK052356 · NIDDK · UNIVERSITY OF FLORIDA · PI BUNGERT, JORG · 1997 to 2017
$4.7M
Regulation of insulator function and globin gene expression by USF and associatedR01HL091929 · NHLBI · UNIVERSITY OF FLORIDA · PI HUANG, SUMING · 2009 to 2013
$2.0M
Transcriptional regulation of TAL1/SCL in normal and malignant hematopoiesisR01HL090589 · NHLBI · UNIVERSITY OF FLORIDA · PI HUANG, SUMING · 2008 to 2012
$1.9M
Functional proteomics in differentiating erythroid cellsR01DK083389 · NIDDK · UNIVERSITY OF FLORIDA · PI BUNGERT, JORG, STROUBOULIS, IOANNIS JOHN · 2010 to 2013
$1.1M
NHLBI NIH HHS R01 HL090589NHLBI NIH HHS R01HL090589NHLBI NIH HHS R01 HL091929NHLBI NIH HHS R01HL091929NIDDK NIH HHS R01 DK052356NIDDK NIH HHS R01DK052356NIDDK NIH HHS R01 DK083389NIDDK NIH HHS R01DK083389
6 · The paper itself

Abstract

Helix-loop-helix (HLH) proteins play a profound role in the process of development and cellular differentiation. Among the HLH proteins expressed in differentiating erythroid cells are the ubiquitous proteins Myc, USF1, USF2, and TFII-I, as well as the hematopoiesis-specific transcription factor Tal1/SCL. All of these HLH proteins exhibit distinct functions during the differentiation of erythroid cells. For example, Myc stimulates the proliferation of erythroid progenitor cells, while the USF proteins and Tal1 regulate genes that specify the differentiated phenotype. This minireview summarizes the known activities of Myc, USF, TFII-I, and Tal11/SCL and discusses how they may function sequentially, cooperatively, or antagonistically in regulating expression programs during the differentiation of erythroid cells.

Indexed as

Cell DifferentiationHelix-Loop-Helix MotifsAnimalsErythroid CellsGene Expression RegulationGlobinsHumansTranscription FactorsGlobinsTranscription Factors

Identifiers

PMID21282467
PMCPMC3135301

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.