Evidence map›Paper›PMID 21282422›Full record

ArticleAntimicrobial agents and chemotherapy2011

Further characterization of Bacillus subtilis antibiotic biosensors and their use for antibacterial mode-of-action studies.

Katherine R Mariner, Nicola Ooi, Deborah Roebuck, Alex J O'Neill, Ian Chopra

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Katherine R MarinerAntimicrobial Research Centre and Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.
Nicola Ooi
Deborah Roebuck
Alex J O'Neill
Ian Chopra
University of Leeds · GB

Funding

Biotechnology and Biological Sciences Research CouncilMedical Research Council G0600810
6 · The paper itself

Abstract

We further examined the usefulness of previously reported Bacillus subtilis biosensors for antibacterial mode-of-action studies. The biosensors could not detect the tRNA synthetase inhibitors mupirocin, indolmycin, and borrelidin, some inhibitors of peptidoglycan synthesis, and most membrane-damaging agents. However, the biosensors confirmed the modes of action of several RNA polymerase inhibitors and DNA intercalators and provided new insights into the possible modes of action of ciprofloxacin, anhydrotetracycline, corralopyronin, 8-hydroxyquinoline, and juglone.

Indexed as

Biosensing TechniquesAmino Acyl-tRNA SynthetasesAnti-Bacterial AgentsBacillus subtilisCiprofloxacinEnzyme InhibitorsFatty AlcoholsIndolesMupirocinNaphthoquinonesOxyquinolineTetracyclines4-epianhydrotetracyclineAmino Acyl-tRNA SynthetasesAnti-Bacterial AgentsborrelidinCiprofloxacinEnzyme InhibitorsFatty AlcoholsIndolesindolmycinjugloneMupirocinNaphthoquinonesOxyquinolineTetracyclines

Identifiers

PMID21282422
PMCPMC3067179
OpenAlexW2133147273

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.