ArticleThe Journal of physiology2011
Ageing reduces the compensatory vasodilatation during hypoxic exercise: the role of nitric oxide.
Article in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Pooled it
- Rho-kinase inhibition improves haemodynamic responses and circulating ATP during hypoxia and moderate intensity handgrip exercise in healthy older adults.The Journal of physiology · 2022Trial
- Acute dietary nitrate supplementation enhances compensatory vasodilation during hypoxic exercise in older adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Trial
- Women at Altitude: Sex-Related Physiological Responses to Exercise in Hypoxia.Sports medicine (Auckland, N.Z.) · 2024Review
- Effect of Exercise Training on Arterial Stiffness in Overweight or Obese Populations.International journal of sports medicine · 2022Article
- Preserved β-adrenergic-mediated vasodilation in skeletal muscle of young adults with obesity despite shifts in cyclooxygenase and nitric oxide synthase.American journal of physiology. Heart and circulatory physiology · 2022Article
- Age and sex differences in sympathetic and hemodynamic responses to hypoxia and cold pressor test.Physiological reports · 2019Article
- Oxygen availability and skeletal muscle oxidative capacity in patients with peripheral artery disease: implications from in vivo and in vitro assessments.American journal of physiology. Heart and circulatory physiology · 2018Article
- Influence of hypoxic stimulation on angiogenesis and satellite cells in mouse skeletal muscle.PloS one · 2018Article
- Impaired peripheral vasodilation during graded systemic hypoxia in healthy older adults: role of the sympathoadrenal system.American journal of physiology. Heart and circulatory physiology · 2017Article
- Article
- β-Adrenergic-mediated vasodilation in young men and women: cyclooxygenase restrains nitric oxide synthase.American journal of physiology. Heart and circulatory physiology · 2016Article
- Greater Beta-Adrenergic Receptor Mediated Vasodilation in Women Using Oral Contraceptives.Frontiers in physiology · 2016Article
- The Spatial Distribution of Absolute Skeletal Muscle Deoxygenation During Ramp-Incremental Exercise Is Not Influenced by Hypoxia.Advances in experimental medicine and biology · 2016Article
- Oral antioxidants improve leg blood flow during exercise in patients with chronic obstructive pulmonary disease.American journal of physiology. Heart and circulatory physiology · 2015Article
- Regulation of increased blood flow (hyperemia) to muscles during exercise: a hierarchy of competing physiological needs.Physiological reviews · 2015Review
- Ascorbic acid does not enhance hypoxia-induced vasodilation in healthy older men.Physiological reports · 2014Article
- Sex and vasodilator responses to hypoxia at rest and during exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Muscle blood flow, hypoxia, and hypoperfusion.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Review
- Contribution of nitric oxide to brachial artery vasodilation during progressive handgrip exercise in the elderly.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We tested the hypotheses that (1) the compensatory vasodilatation in skeletal muscle during hypoxic exercise is attenuated in ageing humans and (2) local inhibition of nitric oxide (NO) synthesis in the forearm of ageing humans will have less impact on the compensatory dilatation during rhythmic exercise with hypoxia, due to a smaller compensatory dilator response. Eleven healthy older subjects (61 ± 2 years) performed forearm exercise (10% and 20% of maximum) during saline infusion (control) and NO synthase inhibition (NG-monomethyl-L-arginine; L-NMMA) under normoxic and normocapnic hypoxic (80% arterial O2 saturation) conditions. Forearm vascular conductance (FVC; ml min⁻¹ (100 mmHg)⁻¹) was calculated from forearm blood flow(ml min⁻¹) and blood pressure (mmHg). To further examine the effects of ageing on the compensatory vasodilator response to hypoxic exercise we compared the difference in ΔFVC (% change compared to respective normoxic exercise trial) between the older subjects (present study) and previously published data from an identical protocol in young subjects. During the control condition, the compensatory vasodilator response to hypoxia was similar between the old and young groups at 10% exercise (28 ± 6% vs. 40 ± 8%, P =0.11) but attenuated at 20% exercise (14 ± 4% vs. 31 ± 6%, P <0.05). L-NMMA during hypoxic exercise only blunted the compensatory vasodilator response in the young group (P <0.05). Our data suggest that ageing reduces the compensatory vasodilator response to hypoxic exercise via blunted NO signalling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.