Trial reportClinical infectious diseases : an official publication of the Infectious Diseases Society of America2011
Patterns and characteristics of hepatitis C transmission clusters among HIV-positive and HIV-negative individuals in the Australian trial in acute hepatitis C.
Trial report in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00192569 (Australian Trial in Acute Hepatitis C), which is not on this map. Cited by 51 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Australian Trial in Acute Hepatitis C
Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- Sexually transmitted hepatitis C virus infections: current trends, and recent advances in understanding the spread in men who have sex with men.Journal of the International AIDS Society · 2019Pooled it
- Cost-effectiveness of diagnostic and therapeutic interventions for chronic hepatitis C: a systematic review of model-based analyses.BMC medical research methodology · 2018Pooled it
- Cytokine profile and viral diversity in the early seronegative stage of community-acquired hepatitis C virus (HCV) infection.Scientific reports · 2023Article
- Patterns and correlates of hepatitis C virus phylogenetic clustering among people living with HIV in Australia in the direct-acting antiviral era: A molecular epidemiology study among participants in the CEASE cohort.Health science reports · 2022Article
- Factors associated with phylogenetic clustering of hepatitis C among people who inject drugs in Baltimore.BMC infectious diseases · 2020Article
- Review on the molecular epidemiology of sexually acquired hepatitis C virus infection in the Asia-Pacific region.Journal of the International AIDS Society · 2020Review
- What is needed to achieve HCV microelimination among HIV-infected populations in Andalusia, Spain: a modeling analysis.BMC infectious diseases · 2020Article
- Trends of recent hepatitis C virus infection among HIV-positive men who have sex with men in Taiwan, 2011-2018.EClinicalMedicine · 2020Article
- Contact tracing for hepatitis C: The case for novel screening strategies as we strive for viral elimination.The International journal on drug policy · 2019Article
- Inconsistent temporal patterns of genetic variation of HCV among high-risk subjects may impact inference of transmission networks.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2019Article
- Hepatitis C virus genotype 1 and 2 recombinant genomes and the phylogeographic history of the 2k/1b lineage.Virus evolution · 2019Article
- A latent class approach to identify multi-risk profiles associated with phylogenetic clustering of recent hepatitis C virus infection in Australia and New Zealand from 2004 to 2015.Journal of the International AIDS Society · 2019Article
- Looking at the positives: proactive management of STIs in people with HIV.AIDS research and therapy · 2018Review
- Complex patterns of Hepatitis-C virus longitudinal clustering in a high-risk population.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2018Article
- Drug use and phylogenetic clustering of hepatitis C virus infection among people who use drugs in Vancouver, Canada: A latent class analysis approach.Journal of viral hepatitis · 2018Article
- Prevalence and mapping of hepatitis C infections among men who have sex with men in New York City.PloS one · 2018Article
- Eliminating hepatitis C virus as a public health threat among HIV-positive men who have sex with men: a multi-modelling approach to understand differences in sexual risk behaviour.Journal of the International AIDS Society · 2018Article
- Modeling HIV-HCV coinfection epidemiology in the direct-acting antiviral era: the road to elimination.BMC medicine · 2017Article
- HCV Cure and Reinfection Among People With HIV/HCV Coinfection and People Who Inject Drugs.Current HIV/AIDS reports · 2017Review
- A molecular transmission network of recent hepatitis C infection in people with and without HIV: Implications for targeted treatment strategies.Journal of viral hepatitis · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundInjecting drug users remain the population at greatest risk of acquiring hepatitis C virus (HCV) infection, although a recent increase in cases of sexually transmitted HCV infection has been observed among human immunodeficiency virus (HIV)-infected individuals. The extent to which these separate epidemics overlap is unknown.
methodsThe Australian Trial in Acute Hepatitis C (ATAHC) enrolled 163 individuals (29% of whom were HIV infected) with recent HCV infection. E1/HVR1 sequences were used to construct phylogenetic trees demonstrating monophyletic clusters or pairs, and viral epidemic history and phylogeography were assessed using molecular clock analysis. Individual clusters were characterized by clinical and demographic characteristics.
resultsTransmission through injection drug use occurred for 73% of subjects, with sexual transmission occurring for 18% (92% of whom were HIV infected). Among 112 individuals with available E1/HVR1 sequences, 23 (20%) were infected with a strain of HCV identical to that of another subject, comprising 4 homologous clusters and 3 monophyletic pairs, the majority of which (78%) were HIV infected. Clusters contained individuals with both injection drug use-related and sex-related acquisition, and in all clusters (except for 1 female HIV-uninfected pair), individuals identified as men who have sex with men, irrespective of HIV status.
conclusionsThis large unique study of HIV-infected and HIV-uninfected individuals with recently acquired HCV infection demonstrates that clustering is common in the HIV-infected population and that it occurred almost invariably among men who have sex with men, irrespective of the actual mode of acquisition. These findings suggest the coexistence of both injection drug use and sexual risk behaviors for individuals in the same social networks and have implications for the development of public health messages. Clinical trial registration. NCT00192569.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.