ArticleThe Journal of biological chemistry2011
Effects of histone acetylation by Piccolo NuA4 on the structure of a nucleosome and the interactions between two nucleosomes.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 38 citations in OpenAlex.
- Unveiling the Conformational Dynamics of the Histone Tails Using Markov State Modeling.Journal of chemical theory and computation · 2025Article
- Conformational Dynamics of the Nucleosomal Histone H2B Tails Revealed by Molecular Dynamics Simulations.Journal of chemical information and modeling · 2024Article
- Review
- Methods to investigate nucleosome structure and dynamics with single-molecule FRET.Methods (San Diego, Calif.) · 2023Article
- The Effects of Histone H2B Ubiquitylations on the Nucleosome Structure and Internucleosomal Interactions.Biochemistry · 2022Article
- Physical Chemistry of Epigenetics: Single-Molecule Investigations.The journal of physical chemistry. B · 2019Review
- Single-molecule FRET method to investigate the dynamics of transcription elongation through the nucleosome by RNA polymerase II.Methods (San Diego, Calif.) · 2019Article
- How Protein Binding Sensitizes the Nucleosome to Histone H3K56 Acetylation.ACS chemical biology · 2019Article
- Effects of histone H2B ubiquitylation on the nucleosome structure and dynamics.Nucleic acids research · 2018Article
- Nucleosome stability measured in situ by automated quantitative imaging.Scientific reports · 2017Article
- Unfolding of core nucleosomes by PARP-1 revealed by spFRET microscopy.AIMS genetics · 2017Article
- Chromatin structure-dependent conformations of the H1 CTD.Nucleic acids research · 2016Article
- Single-Molecule Studies of the Linker Histone H1 Binding to DNA and the Nucleosome.Biochemistry · 2016Article
- Fluorescence Resonance Energy Transfer Characterization of DNA Wrapping in Closed and Open Escherichia coli RNA Polymerase-λP(R) Promoter Complexes.Biochemistry · 2016Article
- CENP-C directs a structural transition of CENP-A nucleosomes mainly through sliding of DNA gyres.Nature structural & molecular biology · 2016Article
- A novel hybrid single molecule approach reveals spontaneous DNA motion in the nucleosome.Nucleic acids research · 2015Article
- Post-translational modifications of histones that influence nucleosome dynamics.Chemical reviews · 2015Review
- Opposing roles of H3- and H4-acetylation in the regulation of nucleosome structure––a FRET study.Nucleic acids research · 2015Article
- Dynamics of nucleosome assembly and effects of DNA methylation.The Journal of biological chemistry · 2015Article
- Sumoylated human histone H4 prevents chromatin compaction by inhibiting long-range internucleosomal interactions.The Journal of biological chemistry · 2014Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
We characterized the effect of histone acetylation on the structure of a nucleosome and the interactions between two nucleosomes. In this study, nucleosomes reconstituted with the Selex "Widom 601" sequence were acetylated with the Piccolo NuA4 complex, which acetylates mainly H4 N-terminal tail lysine residues and some H2A/H3 N-terminal tail lysine residues. Upon the acetylation, we observed directional unwrapping of nucleosomal DNA that accompanies topology change of the DNA. Interactions between two nucleosomes in solution were also monitored to discover multiple transient dinucleosomal states that can be categorized to short-lived and long-lived (∼1 s) states. The formation of dinucleosomes is strongly Mg(2+)-dependent, and unacetylated nucleosomes favor the formation of long-lived dinucleosomes 4-fold as much as the acetylated ones. These results suggest that the acetylation of histones by Piccolo NuA4 disturbs not only the structure of a nucleosome but also the interactions between two nucleosomes. Lastly, we suggest a structural model for a stable dinucleosomal state where the two nucleosomes are separated by ∼2 nm face-to-face and rotated by 34° with respect to each other.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.