Trial reportThe Journal of allergy and clinical immunology2011
The Madison Avenue effect: how drug presentation style influences adherence and outcome in patients with asthma.
Trial report in The Journal of allergy and clinical immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Digital interventions to improve adherence to maintenance medication in asthma.The Cochrane database of systematic reviews · 2022Pooled it
- Placebo Economics: A Systematic Review About the Economic Potential of Utilizing the Placebo Effect.Frontiers in psychiatry · 2019Pooled it
- Pooled it
- White patients' physical responses to healthcare treatments are influenced by provider race and gender.Proceedings of the National Academy of Sciences of the United States of America · 2022Trial
- A patient advocate to facilitate access and improve communication, care, and outcomes in adults with moderate or severe asthma: Rationale, design, and methods of a randomized controlled trial.Contemporary clinical trials · 2017Trial
- What Really Happens in the Home: The Medication Environment of Urban, Minority Youth.The journal of allergy and clinical immunology. In practiceTrial
- An Overview of Adherence-What It Is and Why It Is Important.The journal of allergy and clinical immunology. In practice · 2024Review
- Subgroup Analysis of a Randomized Trial of the Effects of Positive Messaging on Patient-Reported Outcomes with Asthma - Effect of Obesity.Journal of asthma and allergy · 2022Article
- Theoretical asthma self-management program for Taiwanese adolescents with self-efficacy, outcome-expectancy, health behaviour, and asthma symptoms: A randomized controlled trial.Contemporary clinical trials communications · 2020Article
- An American Thoracic Society/National Heart, Lung, and Blood Institute Workshop Report: Addressing Respiratory Health Equality in the United States.Annals of the American Thoracic Society · 2017Review
- Longitudinal associations between asthma control, medication adherence, and quality of life among adolescents: results from a cross-lagged analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2015Article
- Adherence, expectations and the placebo response: why is good adherence to an inert treatment beneficial?Psychology & health · 2014Article
- Recent educational interventions for improvement of asthma medication adherence.Asia Pacific allergy · 2012Article
- Medication adherence in the asthmatic child and adolescent.Current allergy and asthma reports · 2011Review
- Quantifying the proportion of severe asthma exacerbations attributable to inhaled corticosteroid nonadherence.The Journal of allergy and clinical immunology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 8 institutions in 2 countries.
Funding
Abstract
backgroundLittle is known about how drug presentation influences medication adherence.
objectiveTo examine the effect of an educational program aimed at increasing expectations of treatment benefit on medication adherence.
methodsData are analyzed from 99 participants who underwent electronic drug monitoring during the Trial of Asthma Patient Education, a randomized, placebo-controlled, multicenter trial. Participants with suboptimally controlled asthma were randomized to placebo or montelukast in conjunction with a presentation mode that was either neutral or designed to increase outcome expectancy. Adherence was monitored electronically over 4 weeks and was defined as ≥ 80% use of prescribed doses. Outcome expectancy, peak expiratory flow, prebronchodilator FEV₁, asthma control (Juniper asthma control questionnaire), and asthma-related quality of life were assessed at baseline and at the 4-week follow-up.
resultsAverage electronic medication adherence was 69.9%. There was a significant interaction between presentation mode and drug assignment, with participants in the enhanced/montelukast group having a higher change in outcome expectancy (Δ 2.1 points; P < .001) and better medication adherence (odds ratio, 4.0; 95% CI, 1.1-14.3) compared with those in the neutral/placebo group. There was no difference in asthma symptoms, quality of life, or clinical outcomes on the basis of presentation mode. Rather, increased outcome expectancy was associated with modest improvements in asthma symptoms after adjusting for presentation mode, drug assignment, and medication adherence.
conclusionThe use of an enhanced presentation aimed at increasing outcome expectancy may lead to improved medication adherence.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.