ArticleThe American journal of pathology2011
Obliterative airway remodeling: molecular evidence for shared pathways in transplanted and native lungs.
Article in The American journal of pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- The Role of TGF-β in the Association Between Primary Graft Dysfunction and Bronchiolitis Obliterans Syndrome.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2016Trial
- Consequences of telomere dysfunction in fibroblasts, club and basal cells for lung fibrosis development.Nature communications · 2022Article
- Interstitial lung disease in infancy and early childhood: a clinicopathological primer.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Notch2 suppression mimicking changes in human pulmonary hypertension modulates Notch1 and promotes endothelial cell proliferation.American journal of physiology. Heart and circulatory physiology · 2021Article
- [Fibrotic remodeling of the lung following lung and stem-cell transplantation].Der Pathologe · 2021Review
- Connective Tissue Growth Factor Is Overexpressed in Explant Lung Tissue and Broncho-Alveolar Lavage in Transplant-Related Pulmonary Fibrosis.Frontiers in immunology · 2021Article
- Post-infectious Bronchiolitis Obliterans: HRCT, DECT, Pulmonary Scintigraphy Images, and Clinical Follow-up in Eight Children.Frontiers in pediatrics · 2020Article
- Morphological and molecular motifs of fibrosing pulmonary injury patterns.The journal of pathology. Clinical research · 2019Article
- [Lung transplantation : Histomorphological diagnosis and clinical aspects].Der Pathologe · 2019Article
- [Injury patterns in interstitial lung diseases].Der Pathologe · 2018Review
- Comparative analysis of morphological and molecular motifs in bronchiolitis obliterans and alveolar fibroelastosis after lung and stem cell transplantation.The journal of pathology. Clinical research · 2017Article
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- Organizing pneumonia in mice and men.Journal of translational medicine · 2016Article
- [Aberrant reparative tissue remodeling: histopathology and molecular pathology].Der Pathologe · 2014Article
- Expression of angiogenic factors is increased in metastasised renal cell carcinomas.Virchows Archiv : an international journal of pathology · 2014Article
- Tumour angiogenesis in Epstein-Barr virus-associated post-transplant smooth muscle tumours.Clinical sarcoma research · 2014Article
- MicroRNA expression in Epstein-Barr virus-associated post-transplant smooth muscle tumours is related to leiomyomatous phenotype.Clinical sarcoma research · 2013Article
- Expression analysis of leukocytes attracting cytokines in chronic histiocytic intervillositis of the placenta.International journal of clinical and experimental pathology · 2013Article
- Inflammatory signalling associated with brain dead organ donation: from brain injury to brain stem death and posttransplant ischaemia reperfusion injury.Journal of transplantation · 2013Article
- Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obliteration of the small airways is a largely unresolved challenge in pulmonary medicine. It represents either the irreversible cause of functional impairment or a morphologic disorder of limited importance in a multitude of diseases. Bronchiolitis obliterans is a key complication of lung transplantation. No predictive markers for the onset of obliterative remodeling are currently available. To further elucidate the molecular mechanisms of airway remodeling, compartment-specific expression patterns were analyzed in patients. For this purpose, remodeled and nonremodeled bronchioli were isolated from transplanted and nontransplanted lung explants using laser-assisted microdissection (n = 24). mRNA expression of 45 fibrosis-associated genes was measured using quantitative real-time RT-PCR. For 20 genes, protein expression was also analyzed by immunohistochemistry. Infiltrating cells were characterized at conventional histology and immunohistochemistry. Obliterative remodeling of the small airways in transplanted and nontransplanted lungs shared similar grades of chronic inflammation and pivotal fibrotic pathways such as transforming growth factor β signaling and increased collagen expression. Bone morphogenetic protein and thrombospondin signaling, and also matrix metalloproteinases and tissue inhibitor of metalloproteinases, were primarily up-regulated in obliterative airway remodeling in nontransplanted lungs. In transplanted lungs, clinical remodeled bone morphogenetic protein but nonremodeled bronchioli were characterized by a concordant up-regulation of matrix metalloproteinase-9, RANTES, and tissue inhibitor of metalloproteinase-1. These distinct expression patterns warrant further investigation as potential markers of impending airway remodeling, especially for prospective longitudinal molecular profiling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.