Evidence map›Paper›PMID 21281667›Full record

ReviewPreventive medicine2011

The combined effects of exercise and foods in preventing neurological and cognitive disorders.

Fernando Gomez-Pinilla

Abstract readReview
In one paragraph

Review in Preventive medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Fernando Gomez-PinillaDept. of Integrative Biology and Physiology, and Dept. of Neurosurgery, University of California Los Angeles, Los Angeles, CA 90095, USA. fgomezpi@ucla.edu

Funding

Restoration of Homeostasis After Brain TraumaR01NS050465 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOMEZ-PINILLA, FERNANDO · 2005 to 2019
$5.5M
Neurotrophins Support Spinal Cord Learning and RehabilitationR01NS056413 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOMEZ-PINILLA, FERNANDO · 2009 to 2013
$1.8M
Broadly Neuroprotective Drug for TBIRC1NS068473 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOMEZ-PINILLA, FERNANDO · 2009 to 2010
$815k
NINDS NIH HHS NS068473NINDS NIH HHS NS50465-06NINDS NIH HHS NS56413NINDS NIH HHS R01 NS050465NINDS NIH HHS R01 NS056413NINDS NIH HHS RC1 NS068473
6 · The paper itself

Abstract

objectiveExercise and select diets have important influences on health and plasticity of the nervous system, and the molecular mechanisms involved with these actions are starting to be elucidated. New evidence indicates that exercise, in combination with dietary factors, exerts its effects by affecting molecular events related to the management of energy metabolism and synaptic plasticity.

methodsPublished studies in animals and humans describing the effects of exercise and diets in brain plasticity and cognitive abilities are discussed.

resultsNew evidence indicates that exercise and select diets exert their effects by affecting molecular events related to the management of energy metabolism and synaptic plasticity. An important instigator in the molecular machinery stimulated by exercise is brain-derived neurotrophic factor (BDNF), which acts at the interface of metabolism and plasticity.

conclusionsRecent studies show that selected dietary factors share similar mechanisms with exercise, and in some cases they can complement the action of exercise. Therefore, exercise and dietary management appear as a non-invasive and effective strategy to counteract neurological and cognitive disorders.

Indexed as

AnimalsBrain-Derived Neurotrophic FactorBrain InjuriesCognition DisordersCurcuminDietDietary SupplementsDocosahexaenoic AcidsEnergy MetabolismExerciseFatty Acids, Omega-3FoodHumansMotor ActivityNervous System DiseasesNeuronal PlasticityBrain-Derived Neurotrophic FactorCurcuminDocosahexaenoic AcidsFatty Acids, Omega-3

Identifiers

PMID21281667
PMCPMC3258093

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.