ReviewExperimental neurology2012
Gene therapy approaches to enhancing plasticity and regeneration after spinal cord injury.
Review in Experimental neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- Resveratrol: A Natural Compound Targeting the PI3K/Akt/mTOR Pathway in Neurological Diseases.Molecular neurobiology · 2025Review
- MLL1 inhibits the neurogenic potential of SCAPs by interacting with WDR5 and repressing HES1.International journal of oral science · 2023Article
- Lower Motoneuron Dysfunction Impacts Spontaneous Motor Recovery in Acute Cervical Spinal Cord Injury.Journal of neurotrauma · 2023Observational
- Brain and spinal cord trauma: what we know about the therapeutic potential of insulin growth factor 1 gene therapy.Neural regeneration research · 2023Review
- Gene-Modified Stem Cells for Spinal Cord Injury: a Promising Better Alternative Therapy.Stem cell reviews and reports · 2022Review
- Impact of Heterotopic Ossification on Functional Recovery in Acute Spinal Cord Injury.Frontiers in cellular neuroscience · 2022Article
- Effects of lyoprotectants on long-term stability and transfection efficacy of lyophilized poly(lactide-co-glycolide)-graft-polyethylenimine/plasmid DNA polyplexes.Nanomedicine (London, England) · 2021Article
- Planet of the AAVs: The Spinal Cord Injury Episode.Biomedicines · 2021Review
- Comparison of RNAi NgR and NEP1-40 in Acting on Axonal Regeneration After Spinal Cord Injury in Rat Models.Molecular neurobiology · 2017Article
- Gene Expression Profiling in the Injured Spinal Cord ofFrontiers in molecular neuroscience · 2017Article
- Biomaterial-Supported Cell Transplantation Treatments for Spinal Cord Injury: Challenges and Perspectives.Frontiers in cellular neuroscience · 2017Review
- Drug delivery, cell-based therapies, and tissue engineering approaches for spinal cord injury.Journal of controlled release : official journal of the Controlled Release Society · 2015Review
- Sensorimotor Cortex Injection of Adeno-Associated Viral Vector Mediates Knockout of PTEN in Neurons of the Brain and Spinal Cord of Mice.Journal of molecular neuroscience : MN · 2015Article
- Spinal cord injury induced neuropathic pain: Molecular targets and therapeutic approaches.Metabolic brain disease · 2015Review
- Gene delivery strategies to promote spinal cord repair.Biomarker insights · 2015Review
- Comparison of cellular architecture, axonal growth, and blood vessel formation through cell-loaded polymer scaffolds in the transected rat spinal cord.Tissue engineering. Part A · 2014Article
- Spinal cord injury - there is not just one way of treating it.F1000prime reports · 2014Review
- Targeting the full length of the motor end plate regions in the mouse forelimb increases the uptake of fluoro-gold into corresponding spinal cord motor neurons.Frontiers in neurology · 2013Article
- Reprogramming axonal behavior by axon-specific viral transduction.Gene therapy · 2012Article
- Chondroitinase activity can be transduced by a lentiviral vector in vitro and in vivo.Journal of neuroscience methods · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
During the past decades, new insights into mechanisms that limit plasticity and functional recovery after spinal cord injury have spurred the development of novel approaches to enhance axonal regeneration and rearrangement of spared circuitry. Gene therapy may provide one means to address mechanisms that underlie the insufficient regenerative response of injured neurons and can also be used to identify factors important for axonal growth. Several genetic approaches aimed to modulate the environment of injured axons, for example by localized expression of growth factors, to enhance axonal sprouting and regeneration and to guide regenerating axons towards their target have been described. In addition, genetic modification of injured neurons via intraparenchymal injection, or via retrograde transport of viral vectors has been used to manipulate the intrinsic growth capacity of injured neurons. In this review we will summarize some of the progress and limitations of cell transplantation and gene therapy to enhance axonal bridging and regeneration across a lesion site, and to maximize the function, collateral sprouting and connectivity of spared axonal systems.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.