ArticleBiophysical journal2011
Meconium impairs pulmonary surfactant by a combined action of cholesterol and bile acids.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- Comparative biophysical study of clinical surfactants using constrained drop surfactometry.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- Meconium aspiration syndrome: from pathophysiology to treatment.Annals of medicine and surgery (2012) · 2024Review
- Thermodynamic and Structural Study of Budesonide-Exogenous Lung Surfactant System.International journal of molecular sciences · 2024Article
- Time-Dependent Oxidative Alterations in Plasma and Lung Tissue after Meconium Aspiration in a Rabbit Model.Antioxidants (Basel, Switzerland) · 2022Article
- Meconium Aspiration Syndrome in Animal Models: Inflammatory Process, Apoptosis, and Surfactant Inactivation.Animals : an open access journal from MDPI · 2022Review
- Systematic Analysis of Composition, Interfacial Performance and Effects of Pulmonary Surfactant Preparations on Cellular Uptake and Cytotoxicity of Aerosolized Nanomaterials.Small science · 2021Article
- Techniques to evaluate surfactant activity for a personalized therapy of RDS neonates.Biomedical journal · 2021Review
- Pulmonary surfactant and drug delivery: Vehiculization, release and targeting of surfactant/tacrolimus formulations.Journal of controlled release : official journal of the Controlled Release Society · 2021Article
- An adverse outcome pathway for lung surfactant function inhibition leading to decreased lung function.Current research in toxicology · 2021Article
- Atomic Force Microscopy Imaging of Adsorbed Pulmonary Surfactant Films.Biophysical journal · 2020Article
- Controlled hypothermia may improve surfactant function in asphyxiated neonates with or without meconium aspiration syndrome.PloS one · 2018Article
- Inhibition and counterinhibition of Surfacen, a clinical lung surfactant of natural origin.PloS one · 2018Article
- Meconium-induced inflammation and surfactant inactivation: specifics of molecular mechanisms.Pediatric research · 2016Review
- Pneumocytes Assemble Lung Surfactant as Highly Packed/Dehydrated States with Optimal Surface Activity.Biophysical journal · 2015Article
- Surface film formation in vitro by infant and therapeutic surfactants: role of surfactant protein B.Pediatric research · 2015Article
- Transient exposure of pulmonary surfactant to hyaluronan promotes structural and compositional transformations into a highly active state.The Journal of biological chemistry · 2013Article
- Delivery and performance of surfactant replacement therapies to treat pulmonary disorders.Therapeutic delivery · 2013Review
- Exposure to polymers reverses inhibition of pulmonary surfactant by serum, meconium, or cholesterol in the captive bubble surfactometer.Biophysical journal · 2012Article
- New surfactant with SP-B and C analogs gives survival benefit after inactivation in preterm lambs.PloS one · 2012Article
- Advances in the management of meconium aspiration syndrome.International journal of pediatrics · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Mechanisms for meconium-induced inactivation of pulmonary surfactant as part of the meconium aspiration syndrome in newborn infants, to our knowledge, are not clearly understood. Here we have studied the biophysical mechanisms of how meconium affects surface activity of pulmonary surfactant and whether the membrane-perturbing effects of meconium can be mimicked by exposure of surfactant to a mixture of bile acids and cholesterol. Surface activity of pulmonary surfactant complexes purified from animal lungs was analyzed in the absence and in the presence of meconium in standard surface balances and in a captive bubble surfactometer. We have also evaluated accumulation of surfactant at the air-liquid interface by what we believe to be a novel microtiter plate fluorescent assay, and the effect of meconium components on surfactant membrane fluidity using Laurdan fluorescence thermotropic profiles and differential scanning calorimetry thermograms. Rapid interfacial adsorption, low surface tension upon film compression, efficient film replenishment upon expansion, and thermotropic properties of surfactant complexes are all adversely affected by meconium, and, in a similar manner, they are affected by cholesterol/taurocholate mixtures but not by taurocholate alone. We conclude that inhibition of surfactant by meconium can be mimicked by a bile salt-promoted incorporation of excess cholesterol into surfactant complexes. These results highlight the potential pathogenic role of cholesterol-mobilizing agents as a crucial factor resulting in cholesterol induced alterations of structure and dynamics of surfactant membranes and films.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.