ArticleBiophysical journal2011
Continuum model of collective cell migration in wound healing and colony expansion.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Physical models of embryonic epithelial healing.PLoS computational biology · 2026Review
- Initiation of epithelial wound closure by an active instability at the purse string.Biophysical journal · 2025Article
- Capturing the mechanosensitivity of cell proliferation in models of epithelium.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Size-dependent response of cells in epithelial tissue modulated by contractile stress fibers.Biophysical journal · 2023Article
- Skin models of cutaneous toxicity, transdermal transport and wound repair.Burns & trauma · 2023Review
- Collective durotaxis of cohesive cell clusters on a stiffness gradient.The European physical journal. E, Soft matter · 2022Article
- Mathematical Modeling Can Advance Wound Healing Research.Advances in wound care · 2021Review
- Three-dimensional label-free imaging and quantification of migrating cells during wound healing.Biomedical optics express · 2020Article
- Bridging from single to collective cell migration: A review of models and links to experiments.PLoS computational biology · 2020Review
- Biologically-informed neural networks guide mechanistic modeling from sparse experimental data.PLoS computational biology · 2020Article
- Mechanical coordination is sufficient to promote tissue replacement during metamorphosis in Drosophila.The EMBO journal · 2020Article
- Use Microfluidic Chips to Study the Phototaxis of Lung Cancer Cells.International journal of molecular sciences · 2019Article
- Tissue Fluidity Promotes Epithelial Wound Healing.Nature physics · 2019Article
- Sharp interface model for elastic motile cells.The European physical journal. E, Soft matter · 2019Article
- Biomechanics of Collective Cell Migration in Cancer Progression: Experimental and Computational Methods.ACS biomaterials science & engineering · 2019Article
- Article
- Fingering instabilities in tissue invasion: an active fluid model.Royal Society open science · 2018Article
- Epithelial vertex models with active biochemical regulation of contractility can explain organized collective cell motility.APL bioengineering · 2018Article
- Collective cell migration without proliferation: density determines cell velocity and wave velocity.Royal Society open science · 2018Article
- Role of Corneal Stromal Cells on Epithelial Cell Function during Wound Healing.International journal of molecular sciences · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Collective cell migration plays an important role during wound healing and embryo development. Although the exact mechanisms that coordinate such migration are still unknown, experimental studies of moving cell layers have shown that the primary interactions governing the motion of the layer are the force of lamellipodia, the adhesion of cells to the substrate, and the adhesion of cells to each other. Here, we derive a two-dimensional continuum mechanical model of cell-layer migration that is based on a novel assumption of elastic deformation of the layer and incorporates basic mechanical interactions of cells as well as cell proliferation and apoptosis. The evolution equations are solved numerically using a level set method. The model successfully reproduces data from two types of experiments: 1), the contraction of an enterocyte cell layer during wound healing; and 2), the expansion of a radially symmetric colony of MDCK cells, both in the edge migration velocity and in cell-layer density. In accord with experimental observations, and in contrast to reaction-diffusion models, this model predicts a partial wound closure if lamellipod formation is inhibited at the wound edge and gives implications of the effect of spatially restricted proliferation.
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Registered trials
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