ArticleCancer science2011
Oncogenic phosphatase Wip1 is a novel prognostic marker for lung adenocarcinoma patient survival.
Article in Cancer science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- The role of PPM1D in cancer and advances in studies of its inhibitors.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2020Pooled it
- WIP1 phosphatase as pharmacological target in cancer therapy.Journal of molecular medicine (Berlin, Germany) · 2017Review
- Wild-type p53-induced phosphatase 1 is a prognostic marker and therapeutic target in bladder transitional cell carcinoma.Oncology letters · 2017Article
- Association between overexpression of Wip1 and prognosis of patients with non-small cell lung cancer.Oncology letters · 2016Article
- Inhibition of WIP1 phosphatase sensitizes breast cancer cells to genotoxic stress and to MDM2 antagonist nutlin-3.Oncotarget · 2016Article
- WIP1 stimulates migration and invasion of salivary adenoid cystic carcinoma by inducing MMP-9 and VEGF-C.Oncotarget · 2015Article
- PPM1D overexpression predicts poor prognosis in non-small cell lung cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Targeting PPM1D by lentivirus-mediated RNA interference inhibits the tumorigenicity of bladder cancer cells.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2014Article
- PPM1D silencing by RNA interference inhibits the proliferation of lung cancer cells.World journal of surgical oncology · 2014Article
- WIP1 regulates the proliferation and invasion of nasopharyngeal carcinoma in vitro.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- PPM1D is a prognostic marker and therapeutic target in colorectal cancer.Experimental and therapeutic medicine · 2014Article
- Sirt1 is a tumor promoter in lung adenocarcinoma.Oncology letters · 2014Article
- Pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines.Theoretical biology & medical modelling · 2014Article
- Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction.Nature chemical biology · 2014Article
- Knockdown of Wip1 Enhances Sensitivity to Radiation in HeLa Cells Through Activation of p38 MAPK.Oncology research · 2014Article
- Overexpression of wip1 is associated with biologic behavior in human clear cell renal cell carcinoma.PloS one · 2014Article
- Wip1 phosphatase involved in lipopolysaccharide-induced neuroinflammation.Journal of molecular neuroscience : MN · 2013Article
- Protein phosphatase magnesium-dependent 1δ (PPM1D) mRNA expression is a prognosis marker for hepatocellular carcinoma.PloS one · 2013Article
- Molecular determinants of ovarian cancer chemoresistance: new insights into an old conundrum.Annals of the New York Academy of Sciences · 2012Review
- Checkpoint control and cancer.Oncogene · 2012Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA damage response pathways are important for maintaining genomic stability. The oncogenic phosphatase Wip1 plays a crucial role in DNA damage response by inhibiting several cell cycle proteins, including p53. Although Wip1 gene amplification has been reported in various primary tumors, including lung cancer, its biological significance for survival of primary lung tumor patients remains unclear. We investigated the expression of Wip1 in cancer epithelial cells immunohistochemically in 84 consecutive resected cases of lung adenocarcinoma. Increased Wip1 expression was observed in 54 (64.3%) of the 84 cases. Wip1 expression was found to be correlated significantly with two clinicopathological factors: γ-H2AX expression, and invasion to the pulmonary vein. A univariate analysis and log-rank test indicated a significant association between Wip1 expression and lower overall survival rate (P = 0.019 and P = 0.0099, respectively). A multivariate analysis also indicated a statistically significant association between increased Wip1 expression and lower overall survival rate (hazard ratio, 4.3; P = 0.026). The Ki67 index level was higher in the Wip1-positive group than in the negative group (P < 0.04, Mann-Whitney U-test). Moreover, in a subgroup analysis of only stage I patients, increased Wip1 expression was also significantly associated with a lower overall survival rate (P = 0.023, log-rank test). These results indicate that the increased expression of Wip1 in cancer epithelial cells has significant value for tumor progression and the clinical prognosis of patients with primary lung adenocarcinoma.
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