ArticleJournal of biomedical optics
Probe pressure effects on human skin diffuse reflectance and fluorescence spectroscopy measurements.
Article in Journal of biomedical optics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- A neuromorphic robotic electronic skin with active pain and injury perception.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Quantitative estimation of optical properties in bilayer media within the subdiffusive regime using tilted fiber-optic probe diffuse reflectance spectroscopy, part 2: probe design, realization, and experimental validation.Journal of biomedical optics · 2024Article
- Investigating the Influence of Probe Pressure on Human Skin Using Diffusive Reflection Spectroscopy.Micromachines · 2023Article
- Non-contact optical spectroscopy for tumor-sensitive diffuse reflectance and fluorescence measurements on murine subcutaneous tissue models: Monte Carlo modeling and experimental validations.Biomedical optics express · 2023Article
- Handheld diffuse reflectance spectroscopy system for noninvasive quantification of neonatal bilirubin and hemoglobin concentrations: a pilot study.Biomedical optics express · 2023Article
- Understanding the sources of errors inBiomedical optics express · 2021Article
- Needle-compatible miniaturized optoelectronic sensor for pancreatic cancer detection.Science advances · 2020Article
- Diffuse reflectance spectroscopy for breach detection during pedicle screw placement: a first in vivo investigation in a porcine model.Biomedical engineering online · 2020Article
- Parametric imaging of attenuation by optical coherence tomography: review of models, methods, and clinical translation.Journal of biomedical optics · 2020Review
- Article
- Effects of isoflurane anesthesia on physiological parameters in murine subcutaneous tumor allografts measured via diffuse reflectance spectroscopy.Biomedical optics express · 2018Article
- Flexible silicon sensors for diffuse reflectance spectroscopy of tissue.Biomedical optics express · 2017Article
- Diffuse Optical Spectroscopy and Imaging to Detect and Quantify Adipose Tissue Browning.Scientific reports · 2017Article
- Quantitative assessment of hemodynamic and structural characteristics ofBiomedical optics express · 2017Article
- Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis.Journal of visualized experiments : JoVE · 2016Article
- Raman Spectroscopy Differentiates Each Tissue from the Skin to the Spinal Cord: A Novel Method for Epidural Needle Placement?Anesthesiology · 2016Article
- Towards monitoring dysplastic progression in the oral cavity using a hybrid fiber-bundle imaging and spectroscopy probe.Scientific reports · 2016Article
- In vivo measurement of non-keratinized squamous epithelium using a spectroscopic microendoscope with multiple source-detector separations.Proceedings of SPIE--the International Society for Optical Engineering · 2016Article
- The Effect of Probe Pressure on In Vivo Single Fiber Reflectance Spectroscopy.Journal of lasers in medical sciences · 2016Article
- Intraoperative optical assessment of photodynamic therapy response of superficial oral squamous cell carcinoma.Journal of biomedical optics · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Diffuse reflectance and fluorescence spectroscopy are popular research techniques for noninvasive disease diagnostics. Most systems include an optical fiber probe that transmits and collects optical spectra in contact with the suspected lesion. The purpose of this study is to investigate probe pressure effects on human skin spectroscopic measurements. We conduct an in-vivo experiment on human skin tissue to study the short-term (<2 s) and long-term (>30 s) effects of probe pressure on diffuse reflectance and fluorescence measurements. Short-term light probe pressure (P0<9 mN∕mm2) effects are within 0 ± 10% on all physiological properties extracted from diffuse reflectance and fluorescence measurements, and less than 0±5% for diagnostically significant physiological properties. Absorption decreases with site-specific variations due to blood being compressed out of the sampled volume. Reduced scattering coefficient variation is site specific. Intrinsic fluorescence shows a large standard error, although no specific pressure-related trend is observed. Differences in tissue structure and morphology contribute to site-specific probe pressure effects. Therefore, the effects of pressure can be minimized when the pressure is small and applied for a short amount of time; however, long-term and large pressures induce significant distortions in measured spectra.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.