ArticleJournal of biomedical optics
Integrated system for combined Raman spectroscopy-spectral domain optical coherence tomography.
Article in Journal of biomedical optics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Optical biopsy of epithelial cancers by optical coherence tomography (OCT).Lasers in medical science · 2014Pooled it
- Label-free in vivo molecular profiling of the human retina by non-resonant Raman spectroscopy.Communications biology · 2026Article
- Impact of Scattering Variation Measured by Line-Field Confocal Optical Coherence Tomography on Fluorescence Measurement by Optical Spectroscopy: A Study on Phantoms and Human Skin Models.Skin pharmacology and physiology · 2025Article
- Development of a label-free, functional, molecular and structural imaging system combining optical coherence tomography and Raman spectroscopy for in vivo measurement of rat retina.Biomedical optics express · 2025Article
- From Vibrations to Visions: Raman Spectroscopy's Impact on Skin Cancer Diagnostics.Journal of clinical medicine · 2023Review
- Multimodal Raman spectroscopy and optical coherence tomography for biomedical analysis.Journal of biophotonics · 2023Review
- Assessment of demineralized tooth lesions using optical coherence tomography and other state-of-the-art technologies: a review.Biomedical engineering online · 2022Review
- Multimodal Handheld Probe for Characterizing Otitis Media - Integrating Raman Spectroscopy and Optical Coherence Tomography.Frontiers in photonics · 2022Article
- Optical coherence tomography-guided confocal Raman microspectroscopy for rapid measurements in tissues.Biomedical optics express · 2022Article
- Highly accurate colorectal cancer prediction model based on Raman spectroscopy using patient serum.World journal of gastrointestinal oncology · 2020Article
- Nonresonant Raman spectroscopy of isolated human retina samples complying with laser safety regulations forNeurophotonics · 2019Article
- Clinical translation of handheld optical coherence tomography: practical considerations and recent advancements.Journal of biomedical optics · 2017Article
- Raman Plus X: Biomedical Applications of Multimodal Raman Spectroscopy.Sensors (Basel, Switzerland) · 2017Review
- Clinical instrumentation and applications of Raman spectroscopy.Chemical Society reviews · 2016Review
- Co-localized confocal Raman spectroscopy and optical coherence tomography (CRS-OCT) for depth-resolved analyte detection in tissue.Biomedical optics express · 2015Article
- Cell optical density and molecular composition revealed by simultaneous multimodal label-free imaging.Biophysical journal · 2013Article
- Polarization control of Raman spectroscopy optimizes the assessment of bone tissue.Journal of biomedical optics · 2013Article
- Comparing potential early caries assessment methods for teledentistry.BMC oral health · 2013Article
- A clinical instrument for combined raman spectroscopy-optical coherence tomography of skin cancers.Lasers in surgery and medicine · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Raman spectroscopy (RS) and optical coherence tomography (OCT) are powerful tools for optical analysis of tissues with mutually complementary strengths and limitations. OCT excels at visualizing tissue microstructure but lacks molecular specificity, while RS can relay tissue biochemical composition but typically cannot relate microstructure. Previous implementations of combined RS-OCT have utilized a common sample arm while maintaining independent RS and OCT detection arms. We present the design and application of an integrated RS-OCT instrument with a common detection arm for both RS and OCT. The detector is a spectrograph capable of sequential detection of the 855-nm OCT signal and the Raman scatter generated by a 785-nm source. The capabilities of the instrument are demonstrated ex vivo in the calvaria and retina of rodents, as well as in vivo in human skin.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.