Evidence map›Paper›PMID 21280613›Full record

ArticleACS nano2011

Near-infrared fluorescent dye-doped semiconducting polymer dots.

Yuhui Jin, Fangmao Ye, Maxwell Zeigler, Changfeng Wu, Daniel T Chiu

Abstract read
In one paragraph

Article in ACS nano, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Review
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  10. A Modular Fluorescent Probe for Viscosity and Polarity Sensing in DNA Hybrid Mesostructures.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuhui JinDepartment of Chemistry, University of Washington, Seattle, Washington 98195, USA.
Fangmao Ye
Maxwell Zeigler
Changfeng Wu
Daniel T Chiu

Funding

Single-Molecule Studies of Synaptic VesiclesR01NS062725 · NINDS · UNIVERSITY OF WASHINGTON · PI CHIU, DANIEL T · 2008 to 2011
$1.3M
High Sensitivity Detection and Isolation of Circulating Tumor CellsR21CA147831 · NCI · UNIVERSITY OF WASHINGTON · PI CHIU, DANIEL T · 2010 to 2012
$631k
NCI NIH HHS CA 147837NCI NIH HHS R21 CA147831NINDS NIH HHS NS062725NINDS NIH HHS R01 NS062725
6 · The paper itself

Abstract

Near-infrared (NIR) fluorescence sensing is desirable for in vivo biological measurements, but the method is currently limited by the availability of NIR fluorescent markers as well as by their poor performance, such as self-aggregation and dim fluorescence, in a physiological environment. To address this issue, this paper describes a NIR fluorescent polymer dot (Pdot) that emits at 777 nm. This Pdot was comparable in size to a water-soluble NIR quantum dot that emits at 800 nm (ITK Qdot800) but was about four times brighter and with a narrower emission peak. We formed the NIR Pdot by doping the NIR dye, silicon 2,3-naphthalocyanine bis(trihexylsilyloxide) (NIR775), into the matrix of poly (9,9-dioctylfluorene-co-benzothiadiazole) (PFBT) as the Pdot formed using a nanoscale precipitation technique. Free molecules of NIR775 aggregate in aqueous solution, but encapsulating them into the hydrophobic Pdot matrix effectively introduced them into aqueous solution for use in biological studies. Most importantly, the brightness of NIR775 was dramatically enhanced because of the excellent light-harvesting ability of PFBT and the very efficient energy transfer from PFBT to NIR775. We anticipate this bright NIR Pdot will be useful in biological measurements and cellular imaging where strong NIR emission is beneficial.

Indexed as

Infrared RaysSemiconductorsEnergy TransferFluorenesFluorescent DyesNanoparticlesOptical PhenomenaPolymersSilanesSpectrometry, Fluorescencebis(tri-n-hexylsiloxy)(2,3-naphthalocyaninato)siliconFluorenesFluorescent Dyespoly((9,9-dioctylfluorenyl-2,7-diyl)-co-(1,4-benzo-(2,1',3)-thiadiazole))PolymersSilanes

Identifiers

PMID21280613
PMCPMC3043135

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.