Evidence map›Paper›PMID 21280238›Full record

ReviewProteomics. Clinical applications2011

Proteomic analysis of acute kidney injury: biomarkers to mechanisms.

Michael R Bennett, Prasad Devarajan

Abstract readReview
In one paragraph

Review in Proteomics. Clinical applications, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Review
  3. Evaluation of Renal Function with Urinary NGAL and Doppler Ultrasonography in ICU Patients: A 1-Year Observational Pilot Study.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Clinical assessment and pathophysiology ofThe journal of venomous animals and toxins including tropical diseases · 2020
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Marking renal injury: can we move beyond serum creatinine?Translational research : the journal of laboratory and clinical medicine · 2012
    Review
  17. Is it time to evolve past the prerenal azotemia versus acute tubular necrosis classification?Clinical journal of the American Society of Nephrology : CJASN · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Michael R BennettCincinnati Children's Hospital Medical Center, Division of Nephrology and Hypertension, and University of Cincinnati College of Medicine, Department of Pediatrics, Cincinnati, OH 45229, USA. Michael.bennett@cchmc.org
Prasad Devarajan

Funding

Implications of the ASK1/JNK pathway in ARFR01DK069749 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI DEVARAJAN, PRASAD · 2005 to 2009
$1.6M
ANKYRIN: CRUCIAL LINKER IN RENAL CELL APOPTOTIC CASCADESR01DK053289 · NIDDK · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI DEVARAJAN, PRASAD · 2000 to 2003
$674k
NGAL: A novel early biomarker of acute renal injuryR21DK070163 · NIDDK · CHILDREN'S HOSPITAL MED CTR (CINCINNATI) · PI DEVARAJAN, PRASAD · 2004 to 2005
$410k
NIDDK NIH HHS R01 DK053289NIDDK NIH HHS R01 DK069749NIDDK NIH HHS R01 DK53289NIDDK NIH HHS R21 DK070163
6 · The paper itself

Abstract

Acute kidney injury (AKI) is a devastating clinical condition, both in terms of mortality and costs, and is occurring with increasing incidence. Despite better clinical care, the outcomes of AKI have changed little in the last 50 years. This lack of progress is due in part to a lack of early diagnostic biomarkers and a poor understanding of the disease mechanisms. This review will focus on the rapid progress being made in both the understanding of AKI and the promising panel of early biomarkers for AKI that have come out of both direct proteomic analysis of body fluids of AKI patients and more targeted proteomic approaches using clues from other methods such as transcriptomics. This review concludes with a discussion of the future of proteomics and personalized medicine in AKI and the challenges presented in translating these exciting proteomic results to the clinic.

Indexed as

Acute Kidney InjuryProteomicsBiomarkersHumansMetabolomicsBiomarkers

Identifiers

PMID21280238
PMCPMC3049245

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.