ArticleLiver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society2011
Differential effects of plasma and red blood cell transfusions on acute lung injury and infection risk following liver transplantation.
Article in Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 131 citations in OpenAlex.
- A meta-analysis of complications following deceased donor liver transplant.American journal of surgery · 2014Pooled it
- Preventive correction of fibrinolysis with epsilon aminocaproic acid detected by thromboelastometry during liver transplantation.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2025Trial
- Pre-operative predictors of red blood cell transfusion in liver transplantation.Blood transfusion = Trasfusione del sangue · 2017Trial
- Intraoperative allogeneic blood transfusion is not associated with postoperative acute kidney injury and in-hospital mortality in liver transplantation patients: a propensity score matching analysis.Frontiers in medicine · 2026Article
- Role of Lymphopenia in Early prediction of Infection Following Orthotopic Liver Transplantation in Cirrhotic Patients.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Association of Adverse Perinatal Outcomes with Blood Components Transfusion in Patients with Acute Fatty Liver of Pregnancy.International journal of women's health · 2025Article
- The impact of bleeding on outcomes following lung transplantation: a retrospective analysis using the universal definition of perioperative bleeding.Journal of cardiothoracic surgery · 2024Article
- Computer-Aided Diagnosis of Complications After Liver Transplantation Based on Transfer Learning.Interdisciplinary sciences, computational life sciences · 2024Article
- Implementation of a Bleeding Management Algorithm in Liver Transplantation: A Pilot Study.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2024Article
- Patient Blood Management in Liver Transplant-A Concise Review.Biomedicines · 2023Review
- Association of acidosis with coagulopathy and transfusion requirements in liver transplantation.Journal of thrombosis and thrombolysis · 2022Article
- Association of Phlebotomy on Blood Product Transfusion Requirements During Liver Transplantation: An Observational Cohort Study on 1000 Cases.Transplantation direct · 2022Article
- Subjective Difficulty Scale in Liver Transplantation: A Prospective Observational Study.Transplant international : official journal of the European Society for Organ Transplantation · 2022Observational
- A bibliometric analysis of infectious diseases in patients with liver transplantation in the last decade.Annals of translational medicine · 2021Article
- Expert consensus on perioperative management of liver transplantation in adults with acute-on-chronic liver failure.Liver research (Beijing, China) · 2021Article
- Perioperative blood transfusion decreases long-term survival in pediatric living donor liver transplantation.World journal of gastroenterology · 2021Article
- Machine Learning for the Prediction of Red Blood Cell Transfusion in Patients During or After Liver Transplantation Surgery.Frontiers in medicine · 2021Article
- Infection deteriorating hepatitis B virus related acute-on-chronic liver failure: a retrospective cohort study.BMC gastroenterology · 2020Article
- Association of Perioperative Variables and the Acute Respiratory Distress Syndrome in Liver Transplant Recipients.Transplantation direct · 2020Article
- Risk Factors for Transfusion after Orthotopic Liver Transplantation.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2019Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Patients with chronic liver disease have an increased risk of developing transfusion-related acute lung injury (TRALI) from plasma-containing blood products. Similarly, red blood cell transfusions have been associated with postoperative and nosocomial infections in surgical and critical care populations. Patients undergoing liver transplantation receive large amounts of cellular and plasma-containing blood components, but it is presently unclear which blood components are associated with these postoperative complications. A retrospective cohort study of 525 consecutive liver transplant patients revealed a perioperative TRALI rate of 1.3% (7/525, 95% confidence interval = 0.6%-2.7%), which was associated with increases in the hospital mortality rate [28.6% (2/7) versus 2.9% (15/518), P = 0.02] and the intensive care unit length of stay [2 (1-11 days) versus 0 days (0-2 days), P = 0.03]. Only high-plasma-containing blood products (plasma and platelets) were associated with the development of TRALI. Seventy-four of 525 patients (14.1%) developed a postoperative infection, and this was also associated with increased in-hospital mortality [10.8% (8/74) versus 2.0% (9/451), P < 0.01] and a prolonged length of stay. Multivariate logistic regression determined that the number of transfused red blood cell units (adjusted odds ratio = 1.08, 95% confidence interval = 1.02-1.14, P < 0.01), the presence of perioperative renal dysfunction, and reoperation were significantly associated with postoperative infection. In conclusion, patients undergoing liver transplantation have a high risk of developing postoperative complications from blood transfusion. Plasma-containing blood products were associated with the development of TRALI, whereas red blood cells were associated with the development of postoperative infections in a dose-dependent manner.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.