ArticleInternational journal of hematology2011
Transcriptional regulation by GATA1 and GATA2 during erythropoiesis.
Article in International journal of hematology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Quantitative analysis of DNA-GATA1 binding alterations linked to hematopoietic disorders.The FEBS journal · 2026Article
- Advances in the characterization of in vitro-generated red blood cells: from biophysical properties to functional applications.Stem cell research & therapy · 2025Review
- Effect of ginsenoside Rg1 on hematopoietic stem cells in treating aplastic anemia in miceWorld journal of stem cells · 2024Article
- RNA polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation.Developmental cell · 2023Article
- RNA Polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation.medRxiv : the preprint server for health sciences · 2023Article
- Control of ribosomal protein synthesis by the Microprocessor complex.Science signaling · 2021Article
- Proerythroblast Cells of Diamond-Blackfan Anemia Patients WithFrontiers in physiology · 2021Article
- The severe phenotype of Diamond-Blackfan anemia is modulated by heat shock protein 70.Blood advances · 2017Article
- Integrative analysis associates monocytes with insufficient erythropoiesis during acute Plasmodium cynomolgi malaria in rhesus macaques.Malaria journal · 2017Article
- Loss of Forkhead box M1 promotes erythropoiesis through increased proliferation of erythroid progenitors.Haematologica · 2017Article
- Protective vaccination and blood-stage malaria modify DNA methylation of gene promoters in the liver of Balb/c mice.Parasitology research · 2017Article
- Derepression of the DNA Methylation Machinery of theMolecular and cellular biology · 2017Article
- Transcriptome Profiling Reveals Disruption of Innate Immunity in Chronic Heavy Ethanol Consuming Female Rhesus Macaques.PloS one · 2016Article
- GATA2 regulates GATA1 expression through LSD1-mediated histone modification.American journal of translational research · 2016Article
- Histone demethylase LSD1-mediated repression of GATA-2 is critical for erythroid differentiation.Drug design, development and therapy · 2015Article
- Article
- A regulatory network governing Gata1 and Gata2 gene transcription orchestrates erythroid lineage differentiation.International journal of hematology · 2014Review
- Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages.Developmental biology · 2014Article
- A remote GATA2 hematopoietic enhancer drives leukemogenesis in inv(3)(q21;q26) by activating EVI1 expression.Cancer cell · 2014Article
- Dynamic analysis of gene expression and genome-wide transcription factor binding during lineage specification of multipotent progenitors.Cell stem cell · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcription factor GATA1 regulates multiple genes in erythroid lineage cells. However, the means by which GATA1 regulates the expression of target genes during erythropoiesis remains to be elucidated. Three mechanisms have been postulated for the regulation of genes by GATA1. First, individual target genes may have multiple discrete thresholds for cellular GATA1. GATA1 has a dynamic expression profile during erythropoiesis, thus the expression of a set of GATA1 target genes may be triggered at a given stage of differentiation by cellular GATA1. Second, the expression of GATA1 target genes may be modified, at least in part, by GATA2 occupying the GATA-binding motifs. GATA2 is expressed earlier in erythropoiesis than GATA1, and prior GATA2 binding may afford GATA1 access to GATA motifs through epigenetic remodeling and thus facilitate target gene expression. Third, other regulatory molecules specific to each target gene may function cooperatively with GATA1. If GATA1 is required for the expression of such cofactors, a regulatory network will be formed and relevant gene expression will be delayed. We propose that the stage-specific regulation of erythroid genes by GATA1 is tightly controlled through a combination of these mechanisms in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.