ArticleKidney international2011
Nanocrystals seed calcification in more ways than one.
Article in Kidney international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Nano-Sized Hydroxyapatite Induces Apoptosis and Osteogenic Differentiation of Vascular Smooth Muscle Cells via JNK/c-JUN Pathway.International journal of nanomedicine · 2021Article
- Calciprotein particle inhibition explains magnesium-mediated protection against vascular calcification.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020Article
- Magnesium prevents vascular calcification in vitro by inhibition of hydroxyapatite crystal formation.Scientific reports · 2018Article
- Calciphylaxis: from the disease to the diseased.Journal of nephrology · 2015Review
- Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Article
- Arterial calcification in chronic kidney disease: key roles for calcium and phosphate.Circulation research · 2011Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Although much progress has been made in the past five years in understanding the mechanisms leading to accelerated vascular calcification in patients with chronic kidney disease, it remains unclear how an environment high in phosphate can impinge so significantly on the calcification process. The study by Sage et al. highlights an important and novel role for calcium phosphate nanocrystals, produced in a high-phosphate environment, in rapidly driving calcification of vascular smooth muscle cells via enhanced production of bone morphogenetic protein-2.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.