Trial reportSexually transmitted infections2011
Reductions in sexually transmitted infections associated with popular opinion leaders in China in a randomised controlled trial.
Trial report in Sexually transmitted infections, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Structural and community-level interventions for increasing condom use to prevent the transmission of HIV and other sexually transmitted infections.The Cochrane database of systematic reviews · 2014Pooled it
- Systematic review of HIV prevention interventions in China: a health communication perspective.International journal of public health · 2014Pooled it
- HIV/sexual risk reduction interventions in China: a meta-analysis.AIDS patient care and STDs · 2012Pooled it
- An adapted white-coat and warm-heart intervention on nurses' knowledge, general stigmatizing attitudes, and work avoidance behaviors towards HIV: a quasi-experimental study.Journal of occupational health · 2024Trial
- Structural Network Position and Performance of Health Leaders Within an HIV Prevention Trial.AIDS and behavior · 2018Trial
- Assessing outcomes of a stigma-reduction intervention with venue-based analysis.Social psychiatry and psychiatric epidemiology · 2014Trial
- Popular Opinion Leader intervention for HIV stigma reduction in health care settings.AIDS education and prevention : official publication of the International Society for AIDS Education · 2013Trial
- A Rapid Review of HIV-Related Stigma-Reduction Randomized Controlled Trials.AIDS and behavior · 2025Review
- Designing Evidence-Based Preventive Interventions That Reach More People, Faster, and with More Impact in Global Contexts.Annual review of clinical psychology · 2021Article
- Mobile sex-tech apps: How use differs across global areas of high and low gender equality.PloS one · 2020Article
- Developing a Mobile App (LYNX) to Support Linkage to HIV/Sexually Transmitted Infection Testing and Pre-Exposure Prophylaxis for Young Men Who Have Sex With Men: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2019Article
- Condom use following a pilot test of the Popular Opinion Leader intervention in the Barbados Defence Force.Journal of community health · 2013Article
- Controlling the HIV/AIDS epidemic: current status and global challenges.Frontiers in immunology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
objectivesA community level randomised controlled trial of a Community Popular Opinion Leader (C-POL) intervention to reduce bacterial and viral sexually transmitted infections (STIs) and unprotected extramarital sex was carried out over 2 years in five countries. The main study results did not find significant intervention effects. This paper presents a sub-analysis examining the differential intervention impacts among high-risk and low-risk participants in the China site.
methodsFrom 2002-2006, 3912 migrant market vendors aged 18 and 49 years were recruited at an urban site in China. Markets were randomly assigned to the C-POL intervention (N=20 markets; n=1979) or standard-care control condition (N=20; n=1933). Both study condition venues received HIV/STI education, free condoms, STI testing and treatment, and training for pharmacists in antibiotic treatments. In intervention markets, C-POLs were identified and trained to diffuse messages regarding safer sex, STI treatment and partner discussions of sex. The primary biological outcome was incidence of new STIs (chlamydia, gonorrhoea, syphilis, trichomonas, herpes or HIV). The primary sexual behaviour risk outcome was any unprotected extramarital sex in the prior 3 months.
resultsIn unadjusted analyses, women had significantly lower rates of STI infection at 24 months in the C-POL intervention (5.7%) compared to controls (8.3%; p = 0.043). In mixed-effects regression models, intervention participants with STIs at previous assessments were about half as likely to have STIs at 24 months (OR 0.47, 95% CI 0.25 to 0.90) compared to controls.
conclusionsThe C-POL intervention lowers HIV risk among those at highest risk (i.e., with a STI or engaging in high-risk sexual activities) rather than the general population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.