ArticleAmerican journal of respiratory and critical care medicine2011
RIG-like helicase innate immunity inhibits vascular endothelial growth factor tissue responses via a type I IFN-dependent mechanism.
Article in American journal of respiratory and critical care medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
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- Maternal exposure to ultrafine particles enhances influenza infection during pregnancy.Particle and fibre toxicology · 2023Article
- RIG-I agonist SLR10 promotes macrophage M1 polarization during influenza virus infection.Frontiers in immunology · 2023Article
- Endothelial Cells as a Key Cell Type for Innate Immunity: A Focused Review on RIG-I Signaling Pathway.Frontiers in immunology · 2022Review
- RIG-like Helicase Regulation of Chitinase 3-like 1 Axis and Pulmonary Metastasis.Scientific reports · 2016Article
- Critical role of RIG-I-like receptors in inflammation in chronic obstructive pulmonary disease.The clinical respiratory journal · 2016Article
- Aryl hydrocarbon receptor agonists upregulate VEGF secretion from bronchial epithelial cells.Journal of molecular medicine (Berlin, Germany) · 2015Article
- Interferon-α and angiogenic dysregulation in pregnant lupus patients who develop preeclampsia.Arthritis & rheumatology (Hoboken, N.J.) · 2015Article
- Kinase AKT controls innate immune cell development and function.Immunology · 2013Review
- A synthetic TLR3 ligand mitigates profibrotic fibroblast responses by inducing autocrine IFN signaling.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Role of IL-18 in second-hand smoke-induced emphysema.American journal of respiratory cell and molecular biology · 2013Article
- Studies of vascular endothelial growth factor in asthma and chronic obstructive pulmonary disease.Proceedings of the American Thoracic Society · 2011Review
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
rationaleVascular endothelial growth factor (VEGF) regulates vascular, inflammatory, remodeling, and cell death responses. It plays a critical role in normal pulmonary physiology, and VEGF excess and deficiency have been implicated in the pathogenesis of asthma and chronic obstructive pulmonary disease, respectively. Although viruses are an important cause of chronic obstructive pulmonary disease exacerbations and innate responses play an important role in these exacerbations, the effects of antiviral responses on VEGF homeostasis have not been evaluated.
objectivesWe hypothesized that antiviral innate immunity regulates VEGF tissue responses.
methodsWe compared the effects of transgenic VEGF(165) in mice treated with viral pathogen-associated molecular pattern polyinosinic:polycytidylic acid [poly(I:C)], mice treated with live virus, and control mice. MEASUREMENTS AND MAIN
resultsTransgenic VEGF stimulated angiogenesis, edema, inflammation, and mucin accumulation. Each of these was abrogated by poly(I:C). These inhibitory effects were dose dependent, noted when poly(I:C) was administered before and after transgene activation, and mediated by a Toll-like receptor-3-independent and RIG-like helicase (RLH)- and type I IFN receptor-dependent pathway. VEGF stimulated the expression of VEGF receptor-1 and poly(I:C) inhibited this stimulation. Poly(I:C) also inhibited the ability of VEGF to activate extracellular signal-regulated kinase-1, Akt, focal adhesion kinase, and endothelial nitric oxide synthase, and aeroallergen-induced adaptive helper T-cell type 2 inflammation. Influenza and respiratory syncytial virus also inhibited VEGF-induced angiogenesis.
conclusionsThese studies demonstrate that poly(I:C) and respiratory viruses inhibit VEGF-induced tissue responses and adaptive helper T-cell type 2 inflammation and highlight the importance of a RLH- and type I IFN receptor-dependent pathway(s) in these regulatory events. They define a novel link between VEGF and antiviral and RLH innate immune responses and a novel pathway that regulates pulmonary VEGF activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.