ArticleJournal of bacteriology2011
EAL domain protein YdiV acts as an anti-FlhD4C2 factor responsible for nutritional control of the flagellar regulon in Salmonella enterica Serovar Typhimurium.
Article in Journal of bacteriology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed.
- Active removal of inhibitory components drives the flagellar type 3 secretion-specificity switch.mBio · 2026Article
- The last bacterial common ancestor encoded a complex flagellum.bioRxiv : the preprint server for biology · 2026Article
- Molecular strategies ofFrontiers in cellular and infection microbiology · 2026Review
- SanA is an inner membrane protein mediatingMicrobiology spectrum · 2025Article
- SPI-1 virulence gene expression modulates motility of Salmonella Typhimurium in a proton motive force- and adhesins-dependent manner.PLoS pathogens · 2023Article
- Genomic and phenotypic comparison of two variants of multidrug-resistantFrontiers in microbiology · 2023Article
- Article
- Yin and Yang of Biofilm Formation and Cyclic di-GMP Signaling of the Gastrointestinal Pathogen Salmonella enterica Serovar Typhimurium.Journal of innate immunity · 2022Review
- Motility control through an anti-activation mechanism in Agrobacterium tumefaciens.Molecular microbiology · 2021Article
- Saturation mutagenesis charts the functional landscape of Salmonella ProQ and reveals a gene regulatory function of its C-terminal domain.Nucleic acids research · 2021Article
- YeiE Regulates Motility and Gut Colonization in Salmonella enterica Serotype Typhimurium.mBio · 2021Article
- Identification of Three New GGDEF and EAL Domain-Containing Proteins Participating in the Scr Surface Colonization Regulatory Network in Vibrio parahaemolyticus.Journal of bacteriology · 2021Article
- Mutation of hilD in a Salmonella Derby lineage linked to swine adaptation and reduced risk to human health.Scientific reports · 2020Article
- A mathematical model of flagellar gene regulation and construction in Salmonella enterica.PLoS computational biology · 2020Article
- YdiV regulates Escherichia coli ferric uptake by manipulating the DNA-binding ability of Fur in a SlyD-dependent manner.Nucleic acids research · 2020Article
- Two Tandem Mechanisms Control Bimodal Expression of the Flagellar Genes in Salmonella enterica.Journal of bacteriology · 2020Article
- Flagellum-Mediated Mechanosensing and RflP Control Motility State of Pathogenic Escherichia coli.mBio · 2020Article
- Synergistic action of SPI-1 gene expression in Salmonella enterica serovar typhimurium through transcriptional crosstalk with the flagellar system.BMC microbiology · 2019Article
- The GGDEF Domain of the Phosphodiesterase PdeB inJournal of bacteriology · 2019Article
- A Family of Small Intrinsically Disordered Proteins Involved in Flagellum-Dependent Motility in Salmonella enterica.Journal of bacteriology · 2019Article
2 more citing papers are in PubMed but not listed here.
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6 authors.
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Abstract
Flagellar operons are divided into three classes with respect to their transcriptional hierarchy in Salmonella enterica serovar Typhimurium. The class 1 gene products FlhD and FlhC act together in an FlhD(4)C(2) heterohexamer, which binds upstream of the class 2 promoters to facilitate binding of RNA polymerase. In this study, we showed that flagellar expression was much reduced in the cells grown in poor medium compared to those grown in rich medium. This nutritional control was shown to be executed at a step after class 1 transcription. We isolated five Tn5 insertion mutants in which the class 2 expression was derepressed in poor medium. These insertions were located in the ydiV (cdgR) gene or a gene just upstream of ydiV. The ydiV gene is known to encode an EAL domain protein and to act as a negative regulator of flagellar expression. Gene disruption and complementation analyses revealed that the ydiV gene is responsible for nutritional control. Expression analysis of the ydiV gene showed that its translation, but not transcription, was enhanced by growth in poor medium. The ydiV mutation did not have a significant effect on either the steady-state level of flhDC mRNA or that of FlhC protein. Purified YdiV protein was shown in vitro to bind to FlhD(4)C(2) through interaction with FlhD subunit and to inhibit its binding to the class 2 promoter, resulting in inhibition of FlhD(4)C(2)-dependent transcription. Taking these data together, we conclude that YdiV is a novel anti-FlhD(4)C(2) factor responsible for nutritional control of the flagellar regulon.
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