ArticleEukaryotic cell2011
Regulatable Ras activity is critical for proper establishment and maintenance of polarity in Aspergillus fumigatus.
Article in Eukaryotic cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The trial behind it
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Who cites it
12 citing papers in PubMed.
- Overexpression of theJournal of fungi (Basel, Switzerland) · 2020Article
- C-terminus Proteolysis and Palmitoylation Cooperate for Optimal Plasma Membrane Localization of RasA inFrontiers in microbiology · 2018Article
- The Aspergillus fumigatus farnesyltransferase β-subunit, RamA, mediates growth, virulence, and antifungal susceptibility.Virulence · 2017Article
- Orchestration of Morphogenesis in Filamentous Fungi: Conserved Roles for Ras Signaling Networks.Fungal biology reviews · 2015Article
- Non-apoptotic cell death associated with perturbations of macropinocytosis.Frontiers in physiology · 2015Review
- Control of Ras-mediated signaling in Aspergillus fumigatus.Mycopathologia · 2014Review
- Fungal morphogenesis.Cold Spring Harbor perspectives in medicine · 2014Review
- Methuosis: nonapoptotic cell death associated with vacuolization of macropinosome and endosome compartments.The American journal of pathology · 2014Review
- Disparate proteome responses of pathogenic and nonpathogenic aspergilli to human serum measured by activity-based protein profiling (ABPP).Molecular & cellular proteomics : MCP · 2013Article
- Plasma membrane localization is required for RasA-mediated polarized morphogenesis and virulence of Aspergillus fumigatus.Eukaryotic cell · 2012Article
- Ras-Mediated Signal Transduction and Virulence in Human Pathogenic Fungi.Fungal genomics & biology · 2012Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Here we show that expression of a constitutively activated RasA allele, as the sole source of Ras activity, revealed novel Ras-induced phenotypes, including excessive vacuolar expansion and spontaneous lysis of hyphal compartments. These findings highlight the requirement for balanced Ras activity in the establishment and maintenance of polarized growth in filamentous fungi.
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Registered trials
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