ArticleAmerican journal of physiology. Heart and circulatory physiology2011
Restoring leptin signaling reduces hyperlipidemia and improves vascular stiffness induced by chronic intermittent hypoxia.
Article in American journal of physiology. Heart and circulatory physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- History and future of leptin: Discovery, regulation and signaling.Metabolism: clinical and experimental · 2024Review
- Acts of appetite: neural circuits governing the appetitive, consummatory, and terminating phases of feeding.Nature metabolism · 2022Review
- Metabolic syndrome and its components are associated with hypoxemia after surgery for acute type A aortic dissection: an observational study.Journal of cardiothoracic surgery · 2022Observational
- Acid sphingomyelinase downregulation alleviates vascular endothelial leptin resistance in rats.Acta pharmacologica Sinica · 2020Article
- Recent advances in understanding the role of leptin in energy homeostasis.F1000Research · 2020Review
- Gut microbiota regulates cardiac ischemic tolerance and aortic stiffness in obesity.American journal of physiology. Heart and circulatory physiology · 2019Article
- Leptin Restores Endothelial Function via Endothelial PPARγ-Nox1-Mediated Mechanisms in a Mouse Model of Congenital Generalized Lipodystrophy.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Longitudinal micro-ultrasound assessment of the ob/ob mouse model: evaluation of cardiovascular, renal and hepatic parameters.International journal of obesity (2005) · 2018Article
- The Bidirectional Relationship Between Obstructive Sleep Apnea and Metabolic Disease.Frontiers in endocrinology · 2018Review
- Linking Arrhythmias and Adipocytes: Insights, Mechanisms, and Future Directions.Frontiers in physiology · 2018Review
- Killing Me Unsoftly: Causes and Mechanisms of Arterial Stiffness.Arteriosclerosis, thrombosis, and vascular biology · 2017Review
- miR-181b regulates vascular stiffness age dependently in part by regulating TGF-β signaling.PloS one · 2017Article
- Targeting the ROS-HIF-1-endothelin axis as a therapeutic approach for the treatment of obstructive sleep apnea-related cardiovascular complications.Pharmacology & therapeutics · 2016Review
- The impact of chronic intermittent hypoxia on hematopoiesis and the bone marrow microenvironment.Pflugers Archiv : European journal of physiology · 2016Article
- Uncoupling of Vascular Nitric Oxide Synthase Caused by Intermittent Hypoxia.Oxidative medicine and cellular longevity · 2016Article
- Vascular and hepatic impact of short-term intermittent hypoxia in a mouse model of metabolic syndrome.PloS one · 2015Article
- Effects of varying degrees of intermittent hypoxia on proinflammatory cytokines and adipokines in rats and 3T3-L1 adipocytes.PloS one · 2014Article
- Endothelial mechanisms of endothelial dysfunction in patients with obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2012Review
- Leptin levels predict survival in pulmonary arterial hypertension.Pulmonary circulationArticle
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
Abstract
Chronic intermittent hypoxia (IH) during sleep can result from obstructive sleep apnea (OSA), a disorder that is particularly prevalent in obesity. OSA is associated with high levels of circulating leptin, cardiovascular dysfunction, and dyslipidemia. Relationships between leptin and cardiovascular function in OSA and chronic IH are poorly understood. We exposed lean wild-type (WT) and obese leptin-deficient ob/ob mice to IH for 4 wk, with and without leptin infusion, and measured cardiovascular indices including aortic vascular stiffness, endothelial function, cardiac myocyte morphology, and contractile properties. At baseline, ob/ob mice had decreased vascular compliance and endothelial function vs. WT mice. We found that 4 wk of IH decreased vascular compliance and endothelial relaxation responses to acetylcholine in both WT and leptin-deficient ob/ob animals. Recombinant leptin infusion in both strains restored IH-induced vascular abnormalities toward normoxic WT levels. Cardiac myocyte morphology and function were unaltered by IH. Serum cholesterol and triglyceride levels were significantly decreased by leptin treatment in IH mice, as was hepatic stearoyl-Coenzyme A desaturase 1 expression. Taken together, these data suggest that restoring normal leptin signaling can reduce vascular stiffness, increase endothelial relaxation, and correct dyslipidemia associated with IH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.