ArticleThe Plant cell2011
Heterodimers of the Arabidopsis transcription factors bZIP1 and bZIP53 reprogram amino acid metabolism during low energy stress.
Article in The Plant cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 1 of them a synthesis that pooled it.
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Who cites it
116 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-wide transcriptional analysis of rapeseed (Brassica napus L.) responses to heat stress: an integrated RNA-Seq meta-analysis, gene co-expression, and gene regulatory network study.BMC plant biology · 2025Pooled it
- A miR65-MsbZIP11 post-transcriptional regulatory module coordinates saline-alkali stress tolerance in alfalfa (Medicago sativa L.).Plant cell reports · 2026Article
- Energy-sensing kinase OsSnRK1b and its regulator OsCTK1 promote chilling-induced stomatal closure and cold tolerance.Nature communications · 2026Article
- Nuclear SnRK1 Activity Delays Clubroot Development in Arabidopsis by Reducing Sink Strength.Plant, cell & environment · 2026Article
- Many roads lead to a plant cistrome: mapping and interpreting transcription factor binding in plants.Genome biology · 2026Review
- Integrated Gene Regulatory Network Analysis Reveals Coordinated Transcriptional Reprogramming in thePlants (Basel, Switzerland) · 2026Article
- Identification and functional validation of hub genes responding to waterlogging stress during the filling period in quinoa (Chenopodium Quinoa Willd.).BMC plant biology · 2026Article
- Plant bZIPs in Root Environmental Adaptation: From Single-Cell Expression Atlas to Functional Insights.International journal of molecular sciences · 2026Review
- All roads lead to Rome: integrated physiological and transcriptomic analysis of cacao drought response reveals different ways to achieve tolerance in two hybrid clones.Frontiers in plant science · 2026Article
- Molecular resilience: genetic analysis of multiple-stress tolerance (osmotic, salinity, cold and heat) during potato (Frontiers in plant science · 2026Article
- cis- and trans-elements for the transcriptional regulation of sugar responsive genes: from current knowledge to future applications.Plant molecular biology · 2025Review
- Overexpression ofPlants (Basel, Switzerland) · 2025Article
- Single-cell transcriptional profiling in Arabidopsis root exposed to boron toxicity at seedling stages.Plant molecular biology · 2025Article
- Regulation of HvASN1 expression by bZIP transcription factors during barley embryo development and germination.Planta · 2025Article
- Mutations in the floral regulator gene HUA2 restore flowering to the Arabidopsis trehalose 6-phosphate synthase1 (tps1) mutant.Plant physiology · 2025Article
- O-Fucosyltransferase SPINDLY attenuates auxin-induced fruit growth by inhibiting ARF6/8-coactivator mediator complex interaction in Arabidopsis.Nature communications · 2025Article
- Overexpression of the Transcription FactorInternational journal of molecular sciences · 2025Article
- Article
- The Proline Dehydrogenase GeneInternational journal of molecular sciences · 2025Article
- Genome-Wide Analysis of bZIP Transcription Factors and Expression Patterns in Response to Salt and Drought Stress inInternational journal of molecular sciences · 2025Article
56 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Control of energy homeostasis is crucial for plant survival, particularly under biotic or abiotic stress conditions. Energy deprivation induces dramatic reprogramming of transcription, facilitating metabolic adjustment. An in-depth knowledge of the corresponding regulatory networks would provide opportunities for the development of biotechnological strategies. Low energy stress activates the Arabidopsis thaliana group S1 basic leucine zipper transcription factors bZIP1 and bZIP53 by transcriptional and posttranscriptional mechanisms. Gain-of-function approaches define these bZIPs as crucial transcriptional regulators in Pro, Asn, and branched-chain amino acid metabolism. Whereas chromatin immunoprecipitation analyses confirm the direct binding of bZIP1 and bZIP53 to promoters of key metabolic genes, such as ASPARAGINE SYNTHETASE1 and PROLINE DEHYDROGENASE, the G-box, C-box, or ACT motifs (ACTCAT) have been defined as regulatory cis-elements in the starvation response. bZIP1 and bZIP53 were shown to specifically heterodimerize with group C bZIPs. Although single loss-of-function mutants did not affect starvation-induced transcription, quadruple mutants of group S1 and C bZIPs displayed a significant impairment. We therefore propose that bZIP1 and bZIP53 transduce low energy signals by heterodimerization with members of the partially redundant C/S1 bZIP factor network to reprogram primary metabolism in the starvation response.
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