ArticleAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology2011
Association of maternal anemia with increased wheeze and asthma in children.
Article in Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Prenatal folic acid and risk of asthma in children: a systematic review and meta-analysis.The American journal of clinical nutrition · 2013Pooled it
- Anaemia and Maternal Iron Intakes in Pregnancy and Child Asthma: An Observational Analysis From a Longitudinal Cohort.Health science reports · 2026Article
- Machine learning-based early prediction of asthma in preschoolers: The COCOA birth cohort study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Article
- Impact of maternal anemia during pregnancy on neonatal metabolic profiles: evidence from the Beijing Birth Cohort Study.BMC pregnancy and childbirth · 2025Observational
- Malnutrition and Allergies: Tipping the Immune Balance towards Health.Journal of clinical medicine · 2024Review
- [Association of pregnancy factors with cow's milk protein allergy in infants].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2024Article
- Causal relationship between iron deficiency anemia and asthma: a Mendelian randomization study.Frontiers in pediatrics · 2024Article
- Scientific opinion on the tolerable upper intake level for folate.EFSA journal. European Food Safety Authority · 2023Article
- Maternal anemia and long-term respiratory morbidity of the offspring-Results of a population-based cohort.Archives of gynecology and obstetrics · 2023Article
- Associations between maternal complications during pregnancy and childhood asthma: a retrospective cohort study.ERJ open research · 2023Article
- Advances in respiratory physiology in mouse models of experimental asthma.Frontiers in physiology · 2023Review
- Iron-Deficiency in Atopic Diseases: Innate Immune Priming by Allergens and Siderophores.Frontiers in allergy · 2022Review
- Investigating the Links between Lower Iron Status in Pregnancy and Respiratory Disease in Offspring Using Murine Models.Nutrients · 2021Article
- Mineral Micronutrients in Asthma.Nutrients · 2021Review
- Article
- Prevalence of Anemia in Pediatric Patients According to Asthma Control: Propensity Score Analysis.Journal of asthma and allergy · 2021Article
- Maternal iron status during pregnancy and respiratory and atopic outcomes in the offspring: a Mendelian randomisation study.BMJ open respiratory research · 2018Article
- Haemoglobin concentrations in pregnancy and respiratory and allergic outcomes in childhood: Birth cohort study.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2017Article
- Maternal Obesity Affects Inflammatory and Iron Indices in Umbilical Cord Blood.The Journal of pediatrics · 2016Article
- The evaluation of risk factors for recurrent hospitalizations resulting from wheezing attacks in preschool children.Italian journal of pediatrics · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundIncreasing interest has focused on maternal nutrition and micronutrient status during pregnancy and respiratory disease development in the offspring.
objectiveTo examine the relationship between maternal anemia in pregnancy with wheeze and asthma in early childhood.
methodsThe cohort included children of women followed through pregnancy and recontacted when the child was 6 years of age to evaluate respiratory health. Exposure was assessed using maternal anemia diagnosis and hemoglobin (Hgb) < 11 during delivery hospitalization. Study outcomes include wheezing in early childhood; patterns of wheeze from birth to age 6 (early-onset transient wheeze; late-onset wheeze; early-onset persistent wheeze); and diagnosis of childhood asthma.
resultsMaternal anemia was reported by 11.9% of mothers and was associated with recurrent infant wheeze in the first year (adjusted odds ratio [ORa] = 2.17, 95% confidence interval [CI] 1.18, 4.00), wheezing before age 3 (Ora = 2.42, 95% CI 1.38, 4.23), and early-onset transient and early-onset persistent wheeze patterns (Ora = 2.81, 95%CI 1.38, 5.72, and Ora = 2.07, 95% CI 1.02, 4.22), respectively. Among children of mothers with asthma, maternal anemia was associated with recurrent wheeze in year 1 (Ora = 4.22, 95% CI 1.65, 10.80) and wheeze before age 3 (Ora = 2.73, 95% CI 1.17, 6.35). Offspring of mothers with asthma also had increased odds of asthma diagnosis (Ora = 2.53, 95% CI 1.04, 6.17) and current asthma (Ora = 3.46, 95% CI 1.45, 8.26).
conclusionsMaternal anemia during pregnancy is associated with infant respiratory health outcomes. If this observation is replicated, maternal anemia may be a target for intervention and future research.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.