Evidence map›Paper›PMID 21277262›Full record

ReviewTransfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis2011

Molecular genetics and clinical applications for RH.

Willy A Flegel

Open access · greenAbstract readReview
In one paragraph

Review in Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 1 synthesis or guideline pooled it, 199 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Rhesus Box as the Primary Mechanism of RHD Gene Deletion in RhD-Negative Blood Donors from Eastern Iran.International journal of hematology-oncology and stem cell research · 2026
    Article
  7. AlphaGenome-enabled analysis of non-coding regulatory variants underlyingbioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. IntegratingMedicina (Kaunas, Lithuania) · 2025
    Article
  12. Article
  13. Evaluation of the LightCyclerBiomedicines · 2024
    Article
  14. Review
  15. Article
  16. Resolution ofInternational journal of molecular sciences · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Willy A FlegelDepartment of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, United States. bill.flegel@nih.gov
National Institutes of Health Clinical Center · US

Funding

Molecular Immunohematology in Ethiopian Sub-populationsZIACL002123 · CLC · CLINICAL CENTER · PI FLEGEL, WILLY · 2012 to 2025
$0k
Intramural NIH HHS Z99 CL999999
6 · The paper itself

Abstract

Rhesus is the clinically most important protein-based blood group system. It represents the largest number of antigens and the most complex genetics of the 30 known blood group systems. The RHD and RHCE genes are strongly homologous. Some genetic complexity is explained by their close chromosomal proximity and unusual orientation, with their tail ends facing each other. The antigens are expressed by the RhD and the RhCE proteins. Rhesus exemplifies the correlation of genotype and phenotype, facilitating the understanding of general genetic mechanisms. For clinical purposes, genetic diagnostics of Rhesus antigens will improve the cost-effective development of transfusion medicine.

Indexed as

Blood Grouping and CrossmatchingBlood TransfusionMolecular Diagnostic TechniquesAllelesChromosomes, Human, Pair 1Erythroblastosis, FetalEthnicityEvolution, MolecularFemaleFetal BloodForecastingGene DuplicationGene FrequencyGenotypeHumansMaternal-Fetal ExchangeRh-Hr Blood-Group System

Identifiers

PMID21277262
PMCPMC3042511
OpenAlexW1981726677

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.