Evidence map›Paper›PMID 21277195›Full record

ReviewCurrent opinion in genetics & development2011

Peripheral somatosensation: a touch of genetics.

Erin G Reed-Geaghan, Stephen M Maricich

Abstract readReview
In one paragraph

Review in Current opinion in genetics & development, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Merkel Cell-Driven BDNF Signaling Specifies SAI Neuron Molecular and Electrophysiological Phenotypes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016
    Article
  3. Article
  4. T-type calcium channels in chronic pain: mouse models and specific blockers.Pflugers Archiv : European journal of physiology · 2014
    Review
  5. Article
  6. Article
  7. Article
  8. c-Maf is required for the development of dorsal horn laminae III/IV neurons and mechanoreceptive DRG axon projections.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Erin G Reed-GeaghanDepartment of Pediatrics, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, United States.
Stephen M Maricich

Funding

Vitamin D endocrine system and Protection Against Skin TumorlgenesisP30AR039750 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI COOPER, KEVIN D · 1988 to 2015
$9.1M
The role of Atoh1 in the development and function of Merkel cellsR01AR059114 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARICICH, STEPHEN M · 2010 to 2014
$1.6M
Analysis of Spatial & Temporal Dependence of Rhombic Lip Derivatives on Math1K08NS053419 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI MARICICH, STEPHEN M · 2006 to 2010
$857k
NIAMS NIH HHS P30 AR039750NIAMS NIH HHS P30AR39750NIAMS NIH HHS R01 AR059114NIAMS NIH HHS R01AR059114NINDS NIH HHS K08 NS053419NINDS NIH HHS K08NS53419
6 · The paper itself

Abstract

The somatosensory system processes information that organisms 'feel': joint position, muscle stretch, pain, pressure, temperature, and touch. The system is composed of a diverse array of peripheral nerve endings specialized to detect these sensory modalities. Several recent discoveries have shed light on the genetic pathways that control specification and differentiation of these neurons, how they accurately innervate their central and peripheral targets, and the molecules that enable them to detect mechanical stimuli. Here, we review the cadre of genes that control these processes, focusing on mechanosensitive neurons and support cells of the skin that mediate different aspects of the sense of touch.

Indexed as

AnimalsCaenorhabditis elegansDrosophilaGene Regulatory NetworksHumansKeratinocytesMechanotransduction, CellularMerkel CellsMiceNeurogliaPainPeripheral Nervous SystemSensory Receptor CellsTouch

Identifiers

PMID21277195
PMCPMC3097266

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.