ReviewCurrent opinion in genetics & development2011
The genetics of Tourette disorder.
Review in Current opinion in genetics & development, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Identity-by-descent analysis of a large Tourette's syndrome pedigree from Costa Rica implicates genes involved in neuronal development and signal transduction.Molecular psychiatry · 2022Article
- Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors.Molecular psychiatry · 2021Article
- Networks in the Field of Tourette Syndrome.Frontiers in neurology · 2021Review
- Genetic Approaches to Understanding Psychiatric Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017Review
- Pediatric Autoimmune Disorders Associated with Streptococcal Infections and Tourette's Syndrome in Preclinical Studies.Frontiers in neuroscience · 2016Review
- Slitrk Missense Mutations Associated with Neuropsychiatric Disorders Distinctively Impair Slitrk Trafficking and Synapse Formation.Frontiers in molecular neuroscience · 2016Article
- The Genetic Etiology of Tourette Syndrome: Large-Scale Collaborative Efforts on the Precipice of Discovery.Frontiers in neuroscience · 2016Article
- Histidine decarboxylase knockout mice, a genetic model of Tourette syndrome, show repetitive grooming after induced fear.Neuroscience letters · 2015Article
- Corticostriatal interactions in the generation of tic-like behaviors after local striatal disinhibition.Experimental neurology · 2015Article
- The Tourette International Collaborative Genetics (TIC Genetics) study, finding the genes causing Tourette syndrome: objectives and methods.European child & adolescent psychiatry · 2015Article
- Association of ADORA1 rs2228079 and ADORA2A rs5751876 Polymorphisms with Gilles de la Tourette Syndrome in the Polish Population.PloS one · 2015Article
- Dysregulated intracellular signaling in the striatum in a pathophysiologically grounded model of Tourette syndrome.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2014Article
- Review
- Association of the KCNJ5 gene with Tourette Syndrome and Attention-Deficit/Hyperactivity Disorder.Genes, brain, and behavior · 2014Article
- Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice.Neuron · 2014Article
- Common and rare alleles of the serotonin transporter gene, SLC6A4, associated with Tourette's disorder.Movement disorders : official journal of the Movement Disorder Society · 2013Article
- Genetic susceptibility and neurotransmitters in Tourette syndrome.International review of neurobiology · 2013Review
- CNV analysis in Tourette syndrome implicates large genomic rearrangements in COL8A1 and NRXN1.PloS one · 2013Article
- Tourette syndrome and other tic disorders in childhood, adolescence and adulthood.Deutsches Arzteblatt international · 2012Article
- Pathogenetic model for Tourette syndrome delineates overlap with related neurodevelopmental disorders including Autism.Translational psychiatry · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Tourette disorder (TD) is a childhood onset neuropsychiatric syndrome defined by persistent motor and vocal tics. Despite a long-standing consensus for a strong genetic contribution, the pace of discovery compared to other disorders of similar prevalence has been slow, due in part to a paucity of studies and both clinical heterogeneity and a complex genetic architecture. However, the potential for rapid progress is high. Recent rare variant findings have pointed to the importance of copy number variation, the overlap of risks among distinct diagnostic entities, the contribution of novel molecular mechanisms, and the value of family based studies. Finally, analysis of a cohort of sufficient size to identify common polymorphisms of plausible effect is underway, promising key information regarding the contribution of common alleles to TD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.