ArticleChemistry & biology2011
A chemical genetics approach reveals H,K-ATPase-mediated membrane voltage is required for planarian head regeneration.
Article in Chemistry & biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers.
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Who cites it
115 citing papers in PubMed, 196 citations in OpenAlex.
- Transcriptional Profiling of Planarian Regeneration Habituating to Physiological Stressor Reveals Individual and Collective Dynamics.bioRxiv : the preprint server for biology · 2026Article
- Germ layer-specific interaction of ion channels and transporters controls membrane potential and left-right patterning in Xenopus tropicalis.Communications biology · 2026Article
- Beyond Small Molecules: Orchestrating Cell Fate with Engineered Water-Soluble Membrane Proteins.Biomolecules · 2026Article
- Mind Everywhere: A Framework for Conceptualizing Goal-Directedness in Biology and Other Domains-Part One.Biological theory · 2026Article
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- Nanotechnology and Cancer Bioelectricity: Bridging the Gap Between Biology and Translational Medicine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Information integration during bioelectric regulation of morphogenesis of the embryonic frog brain.iScience · 2023Article
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- Bioelectric regulation of intestinal stem cells.Trends in cell biology · 2023Review
- Cytoelectric coupling: Electric fields sculpt neural activity and "tune" the brain's infrastructure.Progress in neurobiology · 2023Article
- Darwin's agential materials: evolutionary implications of multiscale competency in developmental biology.Cellular and molecular life sciences : CMLS · 2023Review
- A Comprehensive conceptual and computational dynamics framework for autonomous regeneration of form and function in biological organisms.PNAS nexus · 2023Article
- Biophysics at the edge of life and death: radical control of apoptotic mechanisms.Frontiers in cell death · 2023Article
- A Computational Approach to Explaining Bioelectrically Induced Persistent, Stochastic Changes of Axial Polarity in Planarian Regeneration.Bioelectricity · 2022Article
- Stability and robustness properties of bioelectric networks: A computational approach.Biophysics reviews · 2021Review
55 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Biophysical signaling is required for both embryonic polarity and regenerative outgrowth. Exploiting endogenous ion transport for regenerative therapies will require direct regulation of membrane voltage. Here, we develop a pharmacological method to target ion transporters, uncovering a role for membrane voltage as a key regulator of anterior polarity in regenerating planaria. Utilizing the highly specific inhibitor, SCH-28080, our data reveal that H(+),K(+)-ATPase-mediated membrane depolarization is essential for anterior gene expression and brain induction. H(+),K(+)-ATPase-independent manipulation of membrane potential with ivermectin confirms that depolarization drives head formation, even at posterior-facing wounds. Using this chemical genetics approach, we demonstrate that membrane voltage controls head-versus-tail identity during planarian regeneration. Our data suggest well-characterized drugs (already approved for human use) might be exploited to control adult stem cell-driven pattern formation during the regeneration of complex structures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.