ArticleDevelopmental biology2011
Identification of a dopaminergic enhancer indicates complexity in vertebrate dopamine neuron phenotype specification.
Article in Developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
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- Transcriptomic networks of gba3 governing specification of the dopaminergic neurons in zebrafish embryos.Genes & genomics · 2022Article
- Brain-wide perception of the emotional valence of light is regulated by distinct hypothalamic neurons.Molecular psychiatry · 2022Article
- α-Synuclein amplifies cytoplasmic peroxide flux and oxidative stress provoked by mitochondrial inhibitors in CNS dopaminergic neurons in vivo.Redox biology · 2020Article
- Multiple convergent hypothalamus-brainstem circuits drive defensive behavior.Nature neuroscience · 2020Article
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- Molecular and cellular determinants of motor asymmetry in zebrafish.Nature communications · 2020Article
- Live imaging of mitochondrial dynamics in CNS dopaminergic neurons in vivo demonstrates early reversal of mitochondrial transport following MPP(+) exposure.Neurobiology of disease · 2016Article
- A Novel Developmental Role for Dopaminergic Signaling to Specify Hypothalamic Neurotransmitter Identity.The Journal of biological chemistry · 2016Article
- Transgenic FingRs for Live Mapping of Synaptic Dynamics in Genetically-Defined Neurons.Scientific reports · 2016Article
- Spatial and Temporal Distribution of Dopaminergic Neurons during Development in Zebrafish.Frontiers in neuroanatomy · 2016Article
- Dopaminergic Control of Locomotor Patterning during Development: A Tail for the Ages.Frontiers in cellular neuroscience · 2016Article
- Whole-brain activity mapping onto a zebrafish brain atlas.Nature methods · 2015Article
- Microfluidic-aided genotyping of zebrafish in the first 48 h with 100% viability.Biomedical microdevices · 2015Article
- A vertebrate-conserved cis-regulatory module for targeted expression in the main hypothalamic regulatory region for the stress response.BMC developmental biology · 2014Article
- Expression of arginine vasotocin receptors in the developing zebrafish CNS.Gene expression patterns : GEP · 2013Article
- Toward developmental models of psychiatric disorders in zebrafish.Frontiers in neural circuits · 2013Review
- Sim1a and Arnt2 contribute to hypothalamo-spinal axon guidance by regulating Robo2 activity via a Robo3-dependent mechanism.Development (Cambridge, England) · 2013Article
- Deep brain photoreceptors control light-seeking behavior in zebrafish larvae.Current biology : CB · 2012Article
- The conserved dopaminergic diencephalospinal tract mediates vertebrate locomotor development in zebrafish larvae.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The dopaminergic neurons of the basal ganglia play critical roles in CNS function and human disease, but specification of dopamine neuron phenotype is poorly understood in vertebrates. We performed an in vivo screen in zebrafish to identify dopaminergic neuron enhancers, in order to facilitate studies on the specification of neuronal identity, connectivity, and function in the basal ganglia. Based primarily on identification of conserved non-coding elements, we tested 54 DNA elements from four species (zebrafish, pufferfish, mouse, and rat), that included 21 genes with known or putative roles in dopaminergic neuron specification or function. Most elements failed to drive CNS expression or did not express specifically in dopaminergic neurons. However, we did isolate a discrete enhancer from the otpb gene that drove specific expression in diencephalic dopaminergic neurons, although it did not share sequence conservation with regulatory regions of otpa or other dopamine-specific genes. For the otpb enhancer, regulation of expression in dopamine neurons requires multiple elements spread across a large genomic area. In addition, we compared our in vivo testing with in silico analysis of genomic regions for genes involved in dopamine neuron function, but failed to find conserved regions that functioned as enhancers. We conclude that regulation of dopaminergic neuron phenotype in vertebrates is regulated by dispersed regulatory elements.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.