ArticleDevelopmental biology2011
Zebrafish retinoic acid receptors function as context-dependent transcriptional activators.
Article in Developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 44 citations in OpenAlex.
- Axon targeting of transcriptionally distinct pioneer neurons is regulated by retinoic acid signaling.Nature communications · 2025Article
- Zebrafish as a Model to Study Retinoic Acid Signaling in Development and Disease.Biomedicines · 2023Review
- Retinoic acid signaling restricts the size of the first heart field within the anterior lateral plate mesoderm.Developmental biology · 2021Article
- Peroxisome proliferator-activated receptor alpha is involved in the temperature-induced sex differentiation of a vertebrate.Scientific reports · 2020Article
- Retinoic Acid Organizes the Zebrafish Vagus Motor Topographic Map via Spatiotemporal Coordination of Hgf/Met Signaling.Developmental cell · 2020Article
- Identifying vitamin A signaling by visualizing gene and protein activity, and by quantification of vitamin A metabolites.Methods in enzymology · 2020Article
- HDAC1-mediated repression of the retinoic acid-responsive gene ripply3 promotes second heart field development.PLoS genetics · 2019Article
- Enhancing regeneration after acute kidney injury by promoting cellular dedifferentiation in zebrafish.Disease models & mechanisms · 2019Article
- Hindbrain induction and patterning during early vertebrate development.Cellular and molecular life sciences : CMLS · 2019Review
- In Silico Identification and Experimental Validation of (-)-Muqubilin A, a Marine Norterpene Peroxide, as PPARα/γ-RXRα Agonist and RARα Positive Allosteric Modulator.Marine drugs · 2019Article
- Nr2f-dependent allocation of ventricular cardiomyocyte and pharyngeal muscle progenitors.PLoS genetics · 2019Article
- RDH10-mediated retinol metabolism and RARα-mediated retinoic acid signaling are required for submandibular salivary gland initiation.Development (Cambridge, England) · 2018Article
- Direct activation of chordoblasts by retinoic acid is required for segmented centra mineralization during zebrafish spine development.Development (Cambridge, England) · 2018Article
- Review
- Retinoic acid and meiosis induction in adult versus embryonic gonads of medaka.Scientific reports · 2016Article
- Comparative analysis of zebrafish bone morphogenetic proteins 2, 4 and 16: molecular and evolutionary perspectives.Cellular and molecular life sciences : CMLS · 2016Article
- Retinoic Acid Signaling Coordinates Macrophage-Dependent Injury and Repair after AKI.Journal of the American Society of Nephrology : JASN · 2016Article
- Visualizing retinoic acid morphogen gradients.Methods in cell biology · 2016Article
- Excessive feedback of Cyp26a1 promotes cell non-autonomous loss of retinoic acid signaling.Developmental biology · 2015Article
- An early requirement for nkx2.5 ensures the first and second heart field ventricular identity and cardiac function into adulthood.Developmental biology · 2015Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
RA receptors (RARs) have been thought to function through a binary repressor-activator mechanism: in the absence of ligand, they function as transcriptional repressors, and, in the presence of ligand, they function as transcriptional activators. This prevailing model of RAR mechanism has been derived mostly from in vitro studies and has not been widely tested in developmental contexts. Here, we investigate whether zebrafish RARs function as transcriptional activators or repressors during early embryonic anterior-posterior patterning. Ectopic expression of wild-type zebrafish RARs does not disrupt embryonic patterning and does not sensitize embryos to RA treatment, indicating that RAR availability is not limiting in the embryo. In contrast, ectopic expression of hyperactive zebrafish RARs induces expression of a RA-responsive reporter transgene as well as ectopic expression of endogenous RA-responsive target genes. However, ectopic expression of dominant negative zebrafish RARs fails to induce embryonic phenotypes that are consistent with loss of RA signaling, despite their ability to function as transcriptional repressors in heterologous cell culture assays. Together, our studies suggest that zebrafish RAR function is context-dependent and that, during early patterning, zebrafish RARs function primarily as transcriptional activators and may only have minimal ability to act as transcriptional repressors. Thus, it seems that the binary model for RAR function does not apply to all in vivo scenarios. Taking into account studies of RA signaling in tunicates and tetrapods, we propose a parsimonious model of the evolution of RAR function during chordate anterior-posterior patterning.
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