ArticleCurrent biology : CB2011
Intertissue mechanical stress affects Frizzled-mediated planar cell polarity in the Drosophila notum epidermis.
Article in Current biology : CB, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 51 citations in OpenAlex.
- Drosophila Transglutaminase preserves the integrity of muscle attachments with and without mechanical strain.Journal of cell science · 2026Article
- Planar cell polarity coordination in a cnidarian embryo provides clues to animal body axis evolution.eLife · 2025Article
- Developmental origin of tendon diversity inFrontiers in physiology · 2023Review
- Forces in stem cells and cancer stem cells.Cells & development · 2022Review
- The Hox transcription factor Ultrabithorax binds RNA and regulates co-transcriptional splicing through an interplay with RNA polymerase II.Nucleic acids research · 2022Article
- Isoform-specific roles of the Drosophila filamin-type protein Jitterbug (Jbug) during development.Genetics · 2021Article
- PCP and Wnt pathway components act in parallel during zebrafish mechanosensory hair cell orientation.Nature communications · 2019Article
- Mechanical Control of Myotendinous Junction Formation and Tendon Differentiation during Development.Frontiers in cell and developmental biology · 2017Review
- Establishment of the Muscle-Tendon Junction During Thorax Morphogenesis in Drosophila Requires the Rho-Kinase.Genetics · 2016Article
- Transient Tissue-Scale Deformation Coordinates Alignment of Planar Cell Polarity Junctions in the Mammalian Skin.Current biology : CB · 2016Article
- Article
- The Drosophila egg chamber-a new spin on how tissues elongate.Integrative and comparative biology · 2014Article
- Shaping the nervous system: role of the core planar cell polarity genes.Nature reviews. Neuroscience · 2013Review
- Mechanical regulation of skeletal development.Current osteoporosis reports · 2013Review
- Misshapen decreases integrin levels to promote epithelial motility and planar polarity in Drosophila.The Journal of cell biology · 2013Article
- Drosophila CK1-γ, gilgamesh, controls PCP-mediated morphogenesis through regulation of vesicle trafficking.The Journal of cell biology · 2012Article
- Expanding the morphogenetic repertoire: perspectives from the Drosophila egg.Developmental cell · 2012Article
- Coupling mechanical deformations and planar cell polarity to create regular patterns in the zebrafish retina.PLoS computational biology · 2012Article
- The frizzled/stan pathway and planar cell polarity in the Drosophila wing.Current topics in developmental biology · 2012Review
- Planar cell polarity: coordinating morphogenetic cell behaviors with embryonic polarity.Developmental cell · 2011Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Frizzled/planar cell polarity (Fz/PCP) signaling controls the orientation of sensory bristles and cellular hairs (trichomes) along the anteroposterior axis of the Drosophila thorax (notum). A subset of the trichome-producing notum cells differentiate as "tendon cells," serving as attachment sites for the indirect flight muscles (IFMs) to the exoskeleton. Through the analysis of chascon (chas), a gene identified by its ability to disrupt Fz/PCP signaling under overexpression conditions, and jitterbug (jbug)/filamin, we show that maintenance of anteroposterior planar polarization requires the notum epithelia to balance mechanical stress generated by the attachment of the IFMs. chas is expressed in notum tendon cells, and its loss of function disturbs cellular orientation at and near the regions where IFMs attach to the epidermis. This effect is independent of the Fz/PCP and fat/dachsous systems. The chas phenotype arises during normal shortening of the IFMs and is suppressed by genetic ablation of the IFMs. chas acts through jbug/filamin and cooperates with MyosinII to modulate the mechanoresponse of notum tendon cells. These observations support the notion that the ability of epithelia to respond to mechanical stress generated by one or more interactions with other tissues during development and organogenesis influences the maintenance of its shape and PCP features.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.