ArticleAquatic toxicology (Amsterdam, Netherlands)2011
Methoxychlor affects multiple hormone signaling pathways in the largemouth bass (Micropterus salmoides) liver.
Article in Aquatic toxicology (Amsterdam, Netherlands), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 31 citations in OpenAlex.
- Phenylalanine Plays Important Roles in Regulating the Capacity of Intestinal Immunity, Antioxidants and Apoptosis in Largemouth Bass (Animals : an open access journal from MDPI · 2023Article
- Assessment of Fish Protein Hydrolysates in Juvenile Largemouth Bass (Frontiers in nutrition · 2022Article
- Ecotoxico-lipidomics: An emerging concept to understand chemical-metabolic relationships in comparative fish models.Comparative biochemistry and physiology. Part D, Genomics & proteomics · 2020Review
- Transcriptome and physiological effects of toxaphene on the liver-gonad reproductive axis in male and female largemouth bass (Micropterus salmoides).Comparative biochemistry and physiology. Part D, Genomics & proteomics · 2020Article
- Steroidogenic acute regulatory protein transcription is regulated by estrogen receptor signaling in largemouth bass ovary.General and comparative endocrinology · 2020Article
- Control of transcriptional repression of the vitellogenin receptor gene in largemouth bass (Micropterus salmoides) by select estrogen receptors isotypes.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Reproductive health indicators of fishes from Pennsylvania watersheds: association with chemicals of emerging concern.Environmental monitoring and assessment · 2014Article
- Methylmercury-induced changes in gene transcription associated with neuroendocrine disruption in largemouth bass (Micropterus salmoides).General and comparative endocrinology · 2014Review
- Applications for next-generation sequencing in fish ecotoxicogenomics.Frontiers in genetics · 2012Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Methoxychlor (MXC) is an organochlorine pesticide that has been shown to have estrogenic activity by activating estrogen receptors and inducing vitellogenin production in male fish. Previous studies report that exposure to MXC induces changes in mRNA abundance of reproductive genes in the liver and testes of largemouth bass (Micropterus salmoides). The objective of the present study was to better characterize the mode of action of MXC by measuring the global transcriptomic response in the male largemouth liver using an oligonucleotide microarray. Microarray analysis identified highly significant changes in the expression of 37 transcripts (p<0.001) (20 induced and 17 decreased) in the liver after MXC injection and a total of 900 expression changes (p<0.05) in transcripts with high homology to known genes. Largemouth bass estrogen receptor alpha (esr1) and androgen receptor (ar) were among the transcripts that were increased in the liver after MXC treatment. Functional enrichment analysis identified the molecular functions of steroid binding and androgen receptor activity as well as steroid hormone receptor activity as being significantly over-represented gene ontology terms. Pathway analysis identified c-fos signaling as being putatively affected through both estrogen and androgen signaling. This study provides evidence that MXC elicits transcriptional effects through the estrogen receptor as well as androgen receptor-mediated pathways in the liver.
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Registered trials
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