ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2011
Modulation of cytokine and chemokine secretions in rhesus monkey trophoblast co-culture with decidual but not peripheral blood monocyte-derived macrophages.
Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Methylome of fetal and maternal monocytes and macrophages at the feto-maternal interface.American journal of reproductive immunology (New York, N.Y. : 1989) · 2012Trial
- M2 macrophage-derived G-CSF promotes trophoblasts EMT, invasion and migration via activating PI3K/Akt/Erk1/2 pathway to mediate normal pregnancy.Journal of cellular and molecular medicine · 2021Article
- Embryotoxic impact of Zika virus in a rhesus macaque in vitro implantation model†.Biology of reproduction · 2020Article
- Macrophage- but not monocyte-derived extracellular vesicles induce placental pro-inflammatory responses.Placenta · 2018Article
- A historical review of blastocyst implantation research.Biology of reproduction · 2018Review
- Macrophages modulate the growth and differentiation of rhesus monkey embryonic trophoblasts.American journal of reproductive immunology (New York, N.Y. : 1989) · 2016Article
- Decoding the chemokine network that links leukocytes with decidual cells and the trophoblast during early implantation.Cell adhesion & migration · 2016Review
- The integrative roles of chemokines at the maternal-fetal interface in early pregnancy.Cellular & molecular immunology · 2014Review
- Differential migration and activation profile of monocytes after trophoblast interaction.PloS one · 2014Article
- Immunomorphological changes in the rhesus monkey endometrium and decidua during the menstrual cycle and early pregnancy.American journal of reproductive immunology (New York, N.Y. : 1989) · 2012Article
- Immunophenotype and cytokine profiles of rhesus monkey CD56bright and CD56dim decidual natural killer cells.Biology of reproduction · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
problemDecidual macrophages are thought to promote pregnancy success, in part through interactions with invading trophoblast cells in hemochorial placentation. However, the factors that constitute this regulatory cross talk are not well understood. METHOD OF STUDY: Rhesus monkey decidual and peripheral blood-derived macrophages were co-cultured with primary Rhesus trophoblasts. Macrophage functions including cell-surface marker expression, antigen uptake and processing, in vitro migration, and cytokine and chemokine secretions were evaluated.
resultsWhile most macrophage functions were unchanged by trophoblast co-culture, changes in the secretion of selected cytokines and the migration of trophoblasts were noted when decidual (but generally, not peripheral blood monocyte-derived) macrophages were cultured with trophoblasts. In addition, basal secretion differed significantly between peripheral blood-derived and decidual macrophages for a broad spectrum of cytokines. When trophoblasts were pre-treated with an anti-Mamu-AG antibody, 25D3, there was no change in cytokine or chemokine secretion.
conclusionMacrophage cytokine expression can be modulated by trophoblast co-culture, but it remains unclear how Mamu-AG is involved.
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Registered trials
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