ArticleBritish journal of pharmacology1990
Tolbutamide excites rat glucoreceptive ventromedial hypothalamic neurones by indirect inhibition of ATP-K+ channels.
Article in British journal of pharmacology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed.
- Exploring the Pathophysiology of ATP-Dependent Potassium Channels in Insulin Resistance.International journal of molecular sciences · 2024Review
- Hypothalamic Irak4 is a genetically controlled regulator of hypoglycemia-induced glucagon secretion.Molecular metabolism · 2022Article
- Ventromedial hypothalamus glucose-inhibited neurones: A role in glucose and energy homeostasis?Journal of neuroendocrinology · 2020Review
- Rapid sensing of l-leucine by human and murine hypothalamic neurons: Neurochemical and mechanistic insights.Molecular metabolism · 2018Article
- Modulation of Excitability of Stellate Neurons in the Ventral Cochlear Nucleus of Mice by ATP-Sensitive Potassium Channels.The Journal of membrane biology · 2018Article
- Oleate induces KNeuroscience · 2017Article
- Recent Advances in the Cellular and Molecular Mechanisms of Hypothalamic Neuronal Glucose Detection.Frontiers in physiology · 2017Article
- Hypothalamic glucose sensing: making ends meet.Frontiers in systems neuroscience · 2014Review
- Continuous hypothalamic K(ATP) activation blunts glucose counter-regulation in vivo in rats and suppresses K(ATP) conductance in vitro.Diabetologia · 2013Article
- Neuroprotective role of ATP-sensitive potassium channels in cerebral ischemia.Acta pharmacologica Sinica · 2013Review
- 2. Hypoglycemia Detection.Translational endocrinology & metabolism · 2012Article
- Current understanding of K ATP channels in neonatal diseases: focus on insulin secretion disorders.Acta pharmacologica Sinica · 2011Review
- Hypoglycemia in type 1 diabetes.Diabetes · 2010Article
- Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis.Cellular and molecular life sciences : CMLS · 2010Review
- Glucose sensing neurons in the ventromedial hypothalamus.Sensors (Basel, Switzerland) · 2010Review
- Glucose sensing during hypoglycemia: lessons from the lab.Diabetes care · 2009Article
- Insulin blunts the response of glucose-excited neurons in the ventrolateral-ventromedial hypothalamic nucleus to decreased glucose.American journal of physiology. Endocrinology and metabolism · 2009Article
- Fasting-induced suppression of LH secretion does not require activation of ATP-sensitive potassium channels.American journal of physiology. Endocrinology and metabolism · 2008Article
- Article
- Bringing light to the dark side of insulin: a journey across the blood-brain barrier.Diabetes · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The sulphonylureas, tolbutamide (0.1-10 mM) and glibenclamide (0.1-100 microM) shown not to inhibit ATP-K+ channel currents when applied to inside-out membrane patches excised from rat cultured cerebral cortex or freshly-dispersed ventromedial hypothalamic nucleus (VMHN) neurones. 2. Saturable binding sites for [3H]-glibenclamide, with similar affinity constants are present in rat cerebral cortex and hypothalamic membranes. The density of binding sites was lower in the hypothalamus than cortex. 3. Intracellular recordings from glucoreceptive VMHN neurones in hypothalamic slices were obtained. In the absence of glucose, tolbutamide (0.1 mM) depolarized these cells, increased membrane resistance and elicited action potentials. 4. Tolbutamide (0.1 mM) inhibited ATP-K+ channel currents and induced action current activity in cell-attached recordings from glucoreceptive VMHN neurones. 5. Glibenclamide (10-500 nM) had no effect per se on glucoreceptive VMHN neurones but did antagonize the actions of tolbutamide. 6. It is concluded that the hypothalamic (and perhaps cortical) sulphonylurea receptors are not directly coupled to ATP-K+ channels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.