ArticleACS nano2011
Evaluation of multivalent, functional polymeric nanoparticles for imaging applications.
Article in ACS nano, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Advances in the Rational Design, Mechanisms, and Applications of Lanthanide Nanoparticles for the Regulation of Reactive Oxygen Species.International journal of nanomedicine · 2026Review
- Is Tumor Cell Specificity Distinct from Tumor Selectivity In Vivo?: A Quantitative NIR Molecular Imaging Analysis of Nanoliposome Targeting.Nano research · 2021Article
- Combined Tumor Environment Triggered Self-Assembling Peptide Nanofibers and Inducible Multivalent Ligand Display for Cancer Cell Targeting with Enhanced Sensitivity and Specificity.Small (Weinheim an der Bergstrasse, Germany) · 2020Article
- TRAIL-functionalized gold nanoparticles selectively trigger apoptosis in polarized macrophages.Nanotheranostics · 2017Article
- Design and Modular Construction of a Polymeric Nanoparticle for Targeted Atherosclerosis Positron Emission Tomography Imaging: A Story of 25% (64)Cu-CANF-Comb.Pharmaceutical research · 2016Article
- Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Nanotechnology to augment immunotherapy for the treatment of glioblastoma multiforme.Journal of neuro-oncology · 2015Review
- RGD-conjugated solid lipid nanoparticles inhibit adhesion and invasion of αvβ3 integrin-overexpressing breast cancer cells.Drug delivery and translational research · 2015Article
- Nanogels from metal-chelating crosslinkers as versatile platforms applied to copper-64 PET imaging of tumors and metastases.Theranostics · 2015Article
- Amphiphilic macromolecules on cell membranes: from protective layers to controlled permeabilization.The Journal of membrane biology · 2014Review
- MS-Monitored Conjugation of Poly(ethylene glycol) Monomethacrylate to RGD Peptides.Journal of applied polymer science. Applied polymer symposium · 2014Article
- Polymeric materials for theranostic applications.Pharmaceutical research · 2014Review
- Core-based lipid nanoparticles as a nanoplatform for delivery of near-infrared fluorescent imaging agents.American journal of nuclear medicine and molecular imaging · 2014Article
- GRGDS-Functionalized Poly(lactide)-graft-poly(ethylene glycol) Copolymers: Combining Thiol-Ene Chemistry with Staudinger Ligation.Macromolecules · 2013Article
- Reduction of nanoparticle avidity enhances the selectivity of vascular targeting and PET detection of pulmonary inflammation.ACS nano · 2013Article
- Nanoparticle PET/CT imaging of natriuretic peptide clearance receptor in prostate cancer.Bioconjugate chemistry · 2013Article
- Tumor targeting and imaging with dual-peptide conjugated multifunctional liposomal nanoparticles.International journal of nanomedicine · 2013Article
- Application of nanoparticles on diagnosis and therapy in gliomas.BioMed research international · 2013Review
- Challenges in design and characterization of ligand-targeted drug delivery systems.Journal of controlled release : official journal of the Controlled Release Society · 2012Review
- Multifunctional nanoparticles: cost versus benefit of adding targeting and imaging capabilities.Science (New York, N.Y.) · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
A series of multivalent, functional polymer nanoparticles with diagnostic/imaging units and targeting ligands for molecular targeting were synthesized with the loading of the chain-end-functionalized GRGDS peptide targeting sequence (model system based on integrin α(v)β(3)) ranging from 0 to 50%. Accurate structural and functional group control in these systems was achieved through a modular approach involving the use of multiple functionalized macromonomer/monomer units combined with living free radical polymerization. In cellulo results show an increase in uptake in α(v)β(3) integrin-positive U87MG glioblastoma cells with increasing RGD loading and a possible upper limit on the effectiveness of the number of RGD peptides for targeting α(v)β(3) integrin. Significantly, this increased targeting efficiency is coupled with in vivo biodistribution results, which show decreased blood circulation and increased liver uptake with increasing RGD loading. The results demonstrate the importance of controlling ligand loading in order to achieve optimal performance for therapeutic and imaging applications for multivalent nanoparticle-based systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.