ArticleJournal of the American Chemical Society2011
Sequence-specific B-DNA flexibility modulates Z-DNA formation.
Article in Journal of the American Chemical Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- MACRO-MOLECULAR CROWDING FAVORS WRITHE IN UNWOUND DNA.bioRxiv : the preprint server for biology · 2026Article
- Nanopore Label-Free Monitoring of B-DNA and Z-DNA Conformational Transition in Real Time.ACS nano · 2026Article
- Computational Simulation and Biophysical Study on Cerium Chloride-Induced B-to-Z Transition in (CG)ACS omega · 2024Article
- Structural determinants of DNA recognition by the NO sensor NsrR and related Rrf2-type [FeS]-transcription factors.Communications biology · 2022Article
- Dynamics Studies of DNA with Non-canonical Structure Using NMR Spectroscopy.International journal of molecular sciences · 2020Review
- Praseodymium promotes B-Z transition in self-assembled DNA nanostructures.RSC advances · 2019Article
- Unraveling the Regulatory G-Quadruplex Puzzle: Lessons From Genome and Transcriptome-Wide Studies.Frontiers in genetics · 2019Review
- The C-terminal D/E-rich domain of MBD3 is a putative Z-DNA mimic that competes for Zα DNA-binding activity.Nucleic acids research · 2018Article
- Sequence preference and structural heterogeneity of BZ junctions.Nucleic acids research · 2018Article
- 2'-Molecules (Basel, Switzerland) · 2018Article
- The Cucurbit[7]Uril-Based Supramolecular Chemistry for Reversible B/Z-DNA Transition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2018Article
- FACT is a sensor of DNA torsional stress in eukaryotic cells.Nucleic acids research · 2017Article
- Studying Z-DNA and B- to Z-DNA transitions using a cytosine analogue FRET-pair.Nucleic acids research · 2016Article
- Lanthanum induced B-to-Z transition in self-assembled Y-shaped branched DNA structure.Scientific reports · 2016Article
- Characterizing RNA Excited States Using NMR Relaxation Dispersion.Methods in enzymology · 2015Article
- Widespread transient Hoogsteen base pairs in canonical duplex DNA with variable energetics.Nature communications · 2014Article
- NAFlex: a web server for the study of nucleic acid flexibility.Nucleic acids research · 2013Article
- Probing sequence-specific DNA flexibility in a-tracts and pyrimidine-purine steps by nuclear magnetic resonance (13)C relaxation and molecular dynamics simulations.Biochemistry · 2012Article
- Incorporation of CC steps into Z-DNA: interplay between B-Z junction and Z-DNA helical formation.Biochemistry · 2012Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Conversion of right-handed B-DNA into left-handed Z-DNA is one of the largest structural transitions in biology that plays fundamental roles in gene expression and regulation. Z-DNA segments must form within genomes surrounded by a sea of B-DNA and require creation of energetically costly B/Z junctions. Here, we show using a combination of natural abundance NMR R(1ρ) carbon relaxation measurements and CD spectroscopy that sequence-specific B-DNA flexibility modulates the thermodynamic propensity to form Z-DNA and the location of B/Z junctions. We observe sequence-specific flexibility in B-DNA spanning fast (ps-ns) and slow (μs-ms) time scales localized at the site of B/Z junction formation. Further, our studies show that CG-repeats play an active role tuning this intrinsic B-DNA flexibility. Taken together, our results suggest that sequence-specific B-DNA flexibility may provide a mechanism for defining the length and location of Z-DNA in genomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.