ArticleCancer causes & control : CCC2011
Variation in folate pathway genes and distal colorectal adenoma risk: a sigmoidoscopy-based case-control study.
Article in Cancer causes & control : CCC, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- MTHFR C677T polymorphism contributes to the risk for gastric cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Susceptibility of Genetic Variations in Methylation Pathway to Gastric Cancer.Pharmacogenomics and personalized medicine · 2022Article
- Article
- Implications of DNA Methylation in Parkinson's Disease.Frontiers in molecular neuroscience · 2017Review
- Global DNA methylation and one-carbon metabolism gene polymorphisms and the risk of breast cancer in the Sister Study.Carcinogenesis · 2014Article
- The effect of multiple single nucleotide polymorphisms in the folic acid pathway genes on homocysteine metabolism.BioMed research international · 2014Article
- Article
- Genetic variation in the base excision repair pathway, environmental risk factors, and colorectal adenoma risk.PloS one · 2013Article
- Comprehensive evaluation of one-carbon metabolism pathway gene variants and renal cell cancer risk.PloS one · 2011Article
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11 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundFolate-associated one-carbon metabolism (FOCM) is an important pathway in colorectal neoplasia risk but data on genetic variation in this pathway are largely limited to studies of single SNPs in selected genes.
methodsWe used a comprehensive tagSNP approach to study the association between genetic variation in 11 genes in the FOCM pathway and risk of incident distal colorectal adenomas in a sigmoidoscopy-based case-control study. We included 655 cases (one or more adenomas) and 695 controls (no adenomas) recruited from one of two Kaiser Permanente clinics between 1991 and 1995. We assessed a total of 159 tagSNPs selected using Haploview Tagger as well as selected non-synonymous SNPs. We used unconditional logistic regression to model the association between SNPs and risk of distal adenomas, assuming a log-additive model.
resultsFive SNPs in the SLC19A1 (RFC1) gene: rs1051266 (G80A), rs283895, rs2236484, rs12482346, and rs2838958 were associated with adenoma risk after correction for multiple testing (all corrected p values ≤ 0.043). The non-synonymous SLC19A1 SNP G80A interacted significantly with the MTHFR C677T genotype (interaction p value = 0.018).
conclusionOur data suggest that genetic variation in SLC19A1 may modify the risk of distal colorectal adenoma.
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