ArticleInflammation2012
Effects of TGF-β and b-FGF on the potential of peripheral blood-borne stem cells and bone marrow-derived stem cells in wound healing in a murine model.
Article in Inflammation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- TGF-β/BMP signaling in skeletal biology: molecular mechanisms, regulatory networks, and therapeutic implications in development, regeneration, and disease.Bone research · 2026Review
- piRNA DQ690018 increased bone mass by promoting the proliferation and osteogenic differentiation of BMSCs.Journal of orthopaedic surgery and research · 2025Article
- Exendin-4 and eldecalcitol synergistically promote osteogenic differentiation of bone marrow mesenchymal stem cells through M2 macrophages polarization via PI3K/AKT pathway.Stem cell research & therapy · 2022Article
- Secretome from Human Mesenchymal Stem Cells-Derived Endothelial Cells Promotes Wound Healing in a Type-2 Diabetes Mouse Model.International journal of molecular sciences · 2022Article
- Immunological profile of periapical endodontic infection in patients undergoing haematopoietic transplantation.Clinical oral investigations · 2021Article
- Amniotic mesenchymal stem cells derived hepatocyte-like cells attenuated liver fibrosis more efficiently by mixed-cell transplantation.International journal of physiology, pathophysiology and pharmacology · 2020Article
- Decisive role of P42/44 mitogen-activated protein kinase in ΔOncotarget · 2017Article
- Radiofrequency treatment induces fibroblast growth factor 2 expression and subsequently promotes neocollagenesis and neoangiogenesis in the skin tissue.Lasers in medical science · 2017Article
- Tissue Engineering and Regenerative Medicine in Iran: Current State of Research and Future Outlook.Molecular biotechnology · 2015Review
- Signalling pathways involved in the process of mesenchymal stem cells differentiating into hepatocytes.Cell proliferation · 2015Review
- Fibrin-based 3D matrices induce angiogenic behavior of adipose-derived stem cells.Acta biomaterialia · 2015Article
- Peripheral Blood Mononuclear Cells Enhance Cartilage Repair in in vivo Osteochondral Defect Model.PloS one · 2015Article
- Molecular pathology of cutaneous melanoma.Melanoma management · 2014Review
- A comparative study of the effects of growth and differentiation factor 5 on muscle-derived stem cells and bone marrow stromal cells in an in vitro tendon healing model.The Journal of hand surgery · 2014Article
- Alternative strategies to manipulate fibrocyte involvement in the fibrotic tissue response: pharmacokinetic inhibition and the feasibility of directed-adipogenic differentiation.Acta biomaterialia · 2014Article
- Stem cell and tissue engineering research in the Islamic republic of Iran.Stem cell reviews and reports · 2012Review
- Corneal myofibroblast biology and pathobiology: generation, persistence, and transparency.Experimental eye research · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peripheral blood fibrocytes make up a newly identified leukocyte subpopulation that displays fibroblast-like properties. These blood-borne cells can rapidly enter the site of injury at the same time as circulating inflammatory cells. Marrow stroma includes a subpopulation of undifferentiated cells that are capable of becoming one of a number of phenotypes, including chondrocytes, osteoblasts, adipocytes, and fibroblasts. Adult human bone marrow contains a minority population of bone marrow mesenchymal stem cells (BMSCs) that contribute to the regeneration of tissues such as bone, cartilage, muscle, ligaments, tendons, fat, and stroma. Evidence that these BMSCs are pluripotent, rather than being a mixture of committed progenitor cells each with a restricted potential, includes their rapid proliferation in culture. We hypothesized that peripheral blood mesenchymal stem cells (PBMSCs) and BMSCs have an effective role in wound healing. In this study, we identified and quantified the marrow stem cells (MSCs) derived from blood and bone marrow recruited and migrated to the wound site. Our results show that the synergistic effects of transforming growth factor-beta (TGF-β) and basic fibroblast growth factor (b-FGF) lead to a significant increase in migration and recruitment of both PBMSCs and BMSCs to the wound site, with more potent effects on PBMSCs as compared with BMSCs. Reverse transcription polymerase chain reaction of collagen type I (COL1A1) transcripts (348 bp) confirmed that TGF-β and b-FGF activate collagen I (production in marrow stem cells at higher transcription levels), with more vigorous effects of TGF-β on PBMSCs as compared with the same condition on BMSCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.