ArticleApoptosis : an international journal on programmed cell death2011
The role of IAP antagonist proteins in the core apoptosis pathway of the mosquito disease vector Aedes aegypti.
Article in Apoptosis : an international journal on programmed cell death, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
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- A broad-spectrum Chromobacterium biolarvicide formulation disrupts mosquito development through gut damage and apoptotic cell death and compromises vector competence.Communications biology · 2026Article
- Factors Affecting Arbovirus Midgut Escape in Mosquitoes.Pathogens (Basel, Switzerland) · 2023Review
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- Defining the mechanisms of action and mosquito larva midgut response to a yeast-encapsulated orange oil larvicide.Parasites & vectors · 2022Article
- Deep Conservation ofInsects · 2021Article
- Clustered rapid induction of apoptosis limits ZIKV and DENV-2 proliferation in the midguts of Aedes aegypti.Communications biology · 2021Article
- Effects of Manipulating Fibroblast Growth Factor Expression on Sindbis Virus Replication In Vitro and inViruses · 2020Article
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- Pro-Apoptotic Function Analysis of the Reaper Homologue IBM1 inInternational journal of molecular sciences · 2020Article
- Development of CS-TPP-dsRNA nanoparticles to enhance RNAi efficiency in the yellow fever mosquito, Aedes aegypti.Scientific reports · 2019Article
- Mosquito Innate Immunity.Insects · 2018Review
- Improving RNAi in the Brown Marmorated Stink Bug: Identification of target genes and reference genes for RT-qPCR.Scientific reports · 2018Article
- Functional Validation of Apoptosis Genes IAP1 and DRONC in Midgut Tissue of the Biting Midge Culicoides sonorensis (Diptera: Ceratopogonidae) by RNAi.Journal of medical entomology · 2017Article
- Apoptosis-related genes control autophagy and influence DENV-2 infection in the mosquito vector, Aedes aegypti.Insect biochemistry and molecular biology · 2016Article
- Rapid selection against arbovirus-induced apoptosis during infection of a mosquito vector.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Novel Genetic and Molecular Tools for the Investigation and Control of Dengue Virus Transmission by Mosquitoes.Current tropical medicine reports · 2014Article
- Article
- Effects of manipulating apoptosis on Sindbis virus infection of Aedes aegypti mosquitoes.Journal of virology · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
While apoptosis regulation has been studied extensively in Drosophila melanogaster, similar studies in other insects, including disease vectors, lag far behind. In D. melanogaster, the inhibitor of apoptosis (IAP) protein DIAP1 is the major negative regulator of caspases, while IAP antagonists induce apoptosis, in part, by binding to DIAP1 and inhibiting its ability to regulate caspases. In this study, we characterized the roles of two IAP antagonists, Michelob_x (Mx) and IMP, in apoptosis in the yellow fever mosquito Aedes aegypti. Overexpression of Mx or IMP caused apoptosis in A. aegypti Aag2 cells, while silencing expression of mx or imp attenuated apoptosis. Addition of recombinant Mx or IMP, but not cytochrome c, to Aag2 cytosolic extract caused caspase activation. Consistent with this finding, AeIAP1 bound and inhibited both initiator and effector caspases from A. aegypti, and Mx and IMP competed with caspases for binding to AeIAP1. However, a difference was observed in the BIR domains responsible for Dronc binding by AeIAP1 versus DIAP1. These findings demonstrate that the mechanisms by which IAP antagonists regulate apoptosis are largely conserved between A. aegypti and D. melanogaster, although subtle differences exist.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.